고려대학교 의과대학 및 의과학연구지원센터 구성원이 아닌 경우에는 본인인증을 통하여 글을 작성할 수 있습니다.
- 본인인증 후 글을 작성할 수 있습니다.
내 명의의 휴대전화로 비밀번호를 재설정 할 수 있습니다.
Romo1 promotes production of reactive oxygen species in tumor cells and development of cancer
Excess amount of reactive oxygen species (ROS) in the body causes diseases such as cancer, diabetes, arthritis and so on. Rising concentration of ROS in the body leads to chronic inflammation and onset of diverse diseases. Mitochondrion is a major cellular organelle generating ROS. Researchers led by Prof. Yoo Young-do in the Graduate School of Medicine at Korea University showed for the first time that a specific protein embedded in the mitochondrial inner membrane promotes generation of ROS and named the protein 'Romo1'. The research team discovered for the first time that Romo1 in mitochondria accelerates production of ROS and development of cancer, and these results will contribute to finding out how to suppress cancer.
Development of new drugs targeting Romo1 requires the knowlege of protein structure of Romo1. However, the existing techniques could not illuminate the protein structure of Romo1 because it is a tiny membrane protein embedded in the inner membrane of mitochondria. The research team used structural bioinformatics to discover the 3D structure of Romo1.
The present study also identified characteristics of Romo1 as a nonselective cation channel in human mitochondria. Moreover, researchers showed that Romo1 is the only protein in the human cell with those features. The 3D structure of Romo1 is expected to be used in developing medicines to treat diseases caused by chronic inflammations.
<Structure of Romo1 embedded in the mitochondrial inner membrane>
pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/29545371
J Cell Biol. 2018 Jun 4;217(6):2059-2071. doi: 10.1083/jcb.201709001. Epub 2018 Mar 15.
Medical students from six countries in Asia shared their experiences in medical research.
Korea University College of Medicine successfully hosted the International Medical Student Research Conference.
The KU International Medical Student Research Conference was held on Nov 9th 2018 at KU College of Medicine.
KU College of Medicine is designing an array of programs to nurture medical students who can actively adapt and play leading roles in a rapidly changing healthcare environment in the era of the 4th Industrial Revolution. The medical student research council has been active since 2010 in helping medical students build their research capabilities through voluntary participation and the nurturing of young medical scientists by offering research opportunities during their undergraduate degrees.
The 9th medical student research council started its activities in December of last year and has 25 research teams with 82 students from the 2nd year premedical course to the 4th year at the college of medicine. The research council has currently carried out medical research with their advisors for a year and has an official opportunity to share their research accomplishments in November. As this year, in particular, marks the 90th anniversary of KU College of Medicine, an international conference was held by inviting medical students from seven medical colleges in five countries such as Hong Kong, Singapore, Japan, Thailand and Taiwan, which have built close relationships with KU.
With about 200 participants including medical students and professors, the conference proceeded in the order of registration, poster presentations, introduction of the medical student research council, oral presentations, discussions, an award ceremony as well as closing remarks. Students from KU College of Medicine took part in 26 poster presentations and 10 oral presentations. Foreign students displayed their research results through four poster presentations and eight oral presentations. Participating students originated from the Chinese University of Hong Kong (CUHK), the University of Hong Kong (HKU), National University of Singapore (NUS), Duke-NUS Medical School, Nagoya University of Japan, Chulalongkorn University of Thailand and National Taiwan University (NTU). Open discussions on the topic of 'medical students' research' yielded many questions and comments from the audience.
Kim Yoon-su, currently in the 2nd year of the premedical course, said "It was quite burdensome for me because every presentation was given in English, while it was a great opportunity for me to meet and share experiences with foreign medical students from diverse countries." Kang Seong-min, currently in his 1st year of the premedical course, said "I was impressed to find that many students are involved in research covering a wide range of topics, and I want to build my research capabilities by participating in the medical student research council." Chatuthanai Savigamin from Chulalongkorn University of Thailand also said "I appreciate KU medical students for presenting me with good memories and I want to build good relationships with them and see them again at international conferences as a doctor.”
Prof. Sun Woong, Head of the Joint Research Program, said "Starting from last year, we have expanded the scope of the existing conference to share outcomes from research. Celebrating the 90th anniversary of the KU College of Medicine this year, it is very meaningful to have a chance to share research experiences with foreign students from leading medical colleges in Asia," he also added "I expect Korean medical students to build their own career as young medical scientists by paving the way in their own research areas."
Lee Hong-sik, Dean of KU College of Medicine stated "We have hosted the International Medical Student Research Conference annually to show students that the process of carrying out research including team work and coordination in a range of environments with a diverse array of cultures is also as critical as getting remarkable research outcomes. He also added "It was a great pleasure to host the international conference led by students and we will promote diverse programs to help medical students grow to be global leading experts in medicine."
Fluctuations in fasting plasma glucose level elevates the risk of developing diabetes by 1.67 times.
The top 25% with high fasting plasma glucose variability has 1.67 times higher risk of developing diabetes.
Preventive care is essential to maintain? low glycemic variability.
For nondiabetic subjects in general medical examination, those with high fasting glycemic variability has a high risk of developing type 2 diabetes (T2D).
Research teams lead by Prof. Choi Kyung-mook and Prof. Kim Jung-a in the endocrinology department at Korea University Guro Hospital have tracked the incidence of type 2 diabetes of 131,744 nondiabetics for 8.3 years from 2007 who went through medical check-ups more than three times between 2002 and 2007. The results showed that the top 25% of those with high glycemic variability had 1.67 times higher risk of developing T2D than the bottom 25%.
Glycemic variability is the change in blood glucose level independent of the mean. After an average 8.3-year-long tracking of subjects in the current cohort research, 9,303 people were diagnosed with T2D during the same period. Among the top 25% with the highest glycemic variability (Group D), 2,846 people were diagnosed with diabetes while the number was 2,083 among the bottom 25% with the lowest glycemic variability (Group A). The results were adjusted for variables such as age, gender, body mass index, family history of diabetes, hypertension, hyperlipidemia, lifestyle factors, and mean fasting plasma glucose.
Prof. Choi Kyung Mook said "Glycemic variability of T2D patients emerged as an important research topic in studies related to diabetic complications and cardiovascular diseases" and "The present study is valuable as the first report showing that fasting glycemic variability of nondiabetics is associated with the risk of developing T2D."
He stressed that prevention of type 2 diabetes requires attention to highly fluctuating blood glucose levels and regular dietary and exercising habits.
The paper was published in the December 2018 issue of Diabetes Care.
pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/30254081
Diabetes Care. 2018 Dec;41(12):2610-2616. doi: 10.2337/dc18-0802. Epub 2018 Sep 25.
Korea University Medical Center makes big strides in becoming a leader in future medicine,
Announcing its mission and vision to lead the future of medicine,
Unveiling a blueprint for futuristic hospitals and selecting 10 leading technologies to advance the future of medicine.
Ensuring the health and happiness of humankind with cutting-edge medical technologies and respect for life
Enabling Future Medicine
Korea University Medical Center (KUMC) is making great strides towards becoming a global leader in biomedicine to better the future of medicine.
Celebrating the 90th anniversary of the College of Medicine in 2018, KUMC declared its ambition and vision to lead the future of medicine in a ceremony held in Inchon Memorial Hall at 5 p.m. on December 12th 2018.
The ceremony was proceeded in the order of a pledge of allegiance to the nation, introduction of guests, congratulatory remarks, vision declaration, video play of leading technologies in future medicine and a toast during a banquet. About 700 guests joined the ceremony including Kim Jae-ho, Chairman of the Board of Directors of the Korea University Foundation, Yeom Jaeho, President of Korea University, Lee Ki-hyung, Vice President of Medical Affairs, Na Chun-gyun, President of the Alumni Association of the College of Medicine as well as Im Young-jin, President of the Korean Hospital Association, Park Gu-seon, Chairman of the Board of Directors of KBioHealth in Osong and Park Hong-jun, President of the Seoul Medical Association.
In the ceremony, KUMC unveiled its mission 'Ensuring the health and happiness of humankind with cutting-edge medical technologies and respect for life.' KUMC was founded in 1928 as the first medical institution for women in Korea who could not see a doctor as they were barred from showing their body to men during the Japanese colonial era. The history of commitments to answer the needs of the era enabled establishment of affiliated hospitals to deliver medical services in Guro and Banwol Industrial Complexes. KUMC announced its goal of writing a new history of medical innovation and contribution to human health through convergent biomedical research in the era of the 4th Industrial Revolution.
KUMC is the sole exemplar in Korea for having two research-oriented hospitals, leading convergent biomedical research by establishing affiliates of a medical holding company for the first time in the history of the Korean medical sector. With advanced research capabilities and concrete aims to realize its mission, KUMC also unveiled the vision of 'Enabling Future Medicine.'
Furthermore, KUMC presented four key strategies in order to make its vision become a reality. KUMC will nurture promising talented individuals into leaders in the 4th Industrial Revolution through 'education for convergent and creative thinking' by collaborating with specialists in diverse areas. As a 'global leader in the biomedical industry', KUMC will also propel next-generation growth momentum into biomedicine with commitments to promote prosperity of the nation. KUMC will lead precision medicine, a major prospect in global medicine, and provide advanced and unique healthcare services for the public through 'customized special treatments' and deliver universal medical services to marginalized and vulnerable people as a medical institution 'realizing people-centered social values.'
KUMC also presented a blueprint for a futuristic hospital. This advanced ‘smart intelligent hospital’ proposed by KUMC connects and utilizes the 4h Industrial Revolution technologies such as IoT, AI, MR and Big Data. KUMC will make all affiliated hospitals a standard for futuristic hospitals including the Anam AI-driven Hospital that started to be built last year with a total construction costs of 350 billion won. Participants of the ceremony gave a rapturous applause after the video demonstration of KUMC's future.
The selection of 10 leading technologies in the next-generation biomedicine drew huge attention from the audience. These ten leading technologies include Cancer Precision Medicine, Cloud-Hospital Information System, AI-based Drug Design, Liquid Biopsy, Human Microbiome, Genome Editing, Patient-on-a-chip, 3D Organ Printing, Wearable Soft Robot and Memory Editing. These technologies will enable KUMC to realize the future of medicine that has thus far been only in the imagination and sci-fi movies.