Basic Science - Physiology

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Jee Hoon Roh Professor

Jee Hoon Roh 교수

노지훈 / Jee Hoon Roh

  • DeptPhysiology
  • RankAssociate Professor
  • MajorNeurodegeneration, Alzheimer’s disease
  • LabMoon-sook Medical Hall Room #721
  • Phone1188
  • Fax+82-2-925-5492
  • Emailalzheimer@korea.ac.kr
Education
2003 M.D. in Medicine. Korea University College of Medicine, Seoul, Korea
2006 M.S. in Neurology. Korea University Graduate School of Medicine, Seoul, Korea
2009 Ph.D. in Neurology. Korea University Graduate School of Medicine, Seoul, Korea
Career
2004 - 2009 Resident / Fellow, Department of Neurology, Korea University Medical Center, Seoul, Korea
2009 - 2010 Fellow, Department of Neurology, Samsung Medical Center, Seoul, Korea
2010 - 2013 Postdoctoral Fellow, Department of Neurology, Washington University in St. Louis, MO, USA
2013 - 2019 Professor, Department of Neurology, Asan Medical Center, Seoul, Korea
2020 - Present Professor, Neuroscience Research Institute, Korea University College of Medicine, Seoul, Korea
2021 - Present Associate Professor, Department of Physiology, Korea University College of Medicine, Seoul, Korea
Activity
2008 - Present Society for Neuroscience, Member
2008 - Present American Academy of Neurology, Member
2009 - Present International Society to Advance Alzheimer Research and Treatment (ISTAART), Member
2014 - Present International Society for Frontotemporal Dementia (ISFTD), Member
2008 - Present Korean Neurological Association (KNA), Member
2009 - Present Korean Dementia Association (KDA), Member
2009 - Present Korean Society of Neurodegenerative Disorders (KSND), Member
2010 - Present Ad hoc reviewer of Nature Reviews Neuroscience, Molecular Psychiatry, Scientific Reports, Journal of Stroke, International Journal of Stroke, Journal of Clinical Neurology, Current Alzheimer Research, Journal of Alzheimer's Disease, Journal of Clinical Neuroscience, NeuroImage, Journal of Neuroimaging, European Radiology, Future Neurology, Experimental Neurobiology, PLoS One, JoVE, Brain Research, Brain and Behavior, BMC Medicine; Editorial Board Member, Experimental Neurobiology (Neurobiology of Diseases Section)
Papers
1. Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Serge Gauthier, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI)*, Dominantly Inherited Alzheimer Network (DIAN) Study Group* & Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group*. Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. NATURE COMMUNICATIONS; 2021 Sep 9;12(1):5346. DOI(10.1038/s41467-021-25492-9). (*DIAN Consortium authorship†) [IF=14.919]
2. Eun-Joo Kim, Seong-Ho Koh, Jungsoon Ha, Duk L Na, Sang Won Seo, Hee-Jin Kim, Kyung Won Park, Jae-Hong Lee, Jee Hoon Roh, Jay C Kwon, Soo Jin Yoon, Na-Yeon Jung, Jee H Jeong, Jae-Won Jang, Hee-Jin Kim, Kee Hyung Park, Seong Hye Choi, SangYun Kim, Young Ho Park, Byeong C Kim, Young-Eun Kim, Hyuk Sung Kwon, Hyun-Hee Park, Jeong-Hwa Jin. Increased telomere length in patients with frontotemporal dementia syndrome. JOURNAL OF THE NEUROLOGICAL SCIENCES;2021 Sep 15;428:117565. DOI(10.1016/j.jns.2021.117565).
3. Hwang J, Kim CM, Kim JE, Oh M, Oh JS, Yoon YW, Kim JS, Lee JH, Roh JH. Clinical Implications of Amyloid-Beta Accumulation in Occipital Lobes in Alzheimer's Continuum. BRAIN SCIENCES; 2021 Sep 18;11(9):1232. DOI(10.3390/brainsci11091232)
4. Kim, M; Kim, SJ; Park, JE; Yun, J; Shim, WH; Oh, JS; Oh, M; Roh, JH; Seo, SW; Oh, SJ; Kim, JS. Combination of automated brain volumetry on MRI and quantitative tau deposition on THK-5351 PET to support diagnosis of Alzheimer's disease. SCIENTIFIC REPORTS; 2021 May 14;11(1):10343. DOI(10.1038/s41598-021-89797-x).
5. Pichet Binette A; Vachon-Presseau, E; Morris, J; Bateman, R; Benzinger, T; Collins, DL; Poirier, J; Breitner, JCS; Villeneuve, S; Allegri, R; Amtashar, F; Bateman, R; Benzinger, T; Berman, S; Bodge, C; Brandon, S; Brooks, W; Buck, J; Buckles, V; Chea, S; Chhatwal, J; Chrem, P; Chui, H; Cinco, J; Clifford, J; Cruchaga, C; D‘Mello, M; Donahue, T; Douglas, J; Edigo, N; Erekin-Taner, N; Fagan, A; Farlow, M; Farrar, A; Feldman, H; Flynn, G; Fox, N; Franklin, E; Fujii, H; Gant, C; Gardener, S; Ghetti, B; Goate, A; Goldman, J; Gordon, B; Graff-Radford, N; Gray, J; Gurney, J; Hassenstab, J; Hirohara, M; Holtzman, D; Hornbeck, R; DiBari, SH; Ikeuchi, T; Ikonomovic, S; Jerome, G; Jucker, M; Karch, C; Kasuga, K; Kawarabayashi, T; Klunk, W; Koeppe, R; Kuder-Buletta, E; Laske, C; Lee, J-H; Levin, J; Marcus, D; Martins, R; Mason, NS; Masters, C; Maue-Dreyfus, D; McDade, E; Montoya, L; Mori, H; Morris, J; Nagamatsu, A; Neimeyer, K; Noble, J; Norton, J; Perrin, R; Raichle, M; Ringman, J; Roh, JH; Salloway, S; Schofield, P; Shimada, H; Shiroto, T; Shoji, M; Sigurdson, W; Sohrabi, H; Sparks, P; Suzuki, K; Swisher, L; Taddei, K; Wang, J; Wang, P; Weiner, M; Wolfsberger, M; Xiong, C; Xu, X; Tam, A; Labonte, A; Pichet BA; Faubert, AM; Mathieu, A; Madjar, C; Carrier, CE; Dansereau, C; Kazazian, C; Lepage, C; Picard, C; Maillet, D; Michaud, D; Couture, D; Dea, D; Cuello, C; Barkun, A; Evans, A; Courcot, B; Tardif, C; Debacker, C; Jack, CR; Fontaine, D; Knopman, DS; Maultaup, G; Near, J; Leoutsakos, J; Maltais, JR; Brandt, J; Pruessner, J; Morris, JC.; Breitner, JCS; Poirier, J; Cheewakriengkrai, L; Munter, LM; Collins, L; Chakravarty, M; Sager, MA; Dauar-Tedeschi, M; Eisenberg, M; Rajah, N; Aisen, P; Toussaint, J; Rosa-Neto, P; Bellec, P; Kostopoulos, P; Etienne, P; Tariot, PN.; Orban, P; Sperling, RA.; Hoge, R; Thomas, RG.; Gauthier, S; Craft, S; Villeneuve, S; Montine, TJ.; Nair, V; Bohbot, V; Venugopalan, V; Fonov, V; Ituria-Medina, Y; Khachaturian, ZS.; Teigner, E; Anthal, E; Yu, E; Ferdinand, F; Pogossova, G; Mayrand, G; Duclair, G; Gagne, G; Newbold-Fox, H; Leppert, I; Vallee, I; Vogel, JW.; Tremblay-Mercier, J; Frenette, J; Frappier, J; Kat, J; Miron, J; Wan, K; Mahar, L; Carmo, L; Theroux, L; Dadar, M; Dufour, M; Lafaille-Magnan, ME; Appleby, M; Savard, M; Tuwaig, M; Petkova, M; Rioux, P; Meyer, PF; El-Khoury, R; Gordon, R; Giles, R; Das, S; Wang, S; Tabrizi, S; Mathotaarachchi, S; Dubuc, S; Lee, T; Beaudry, T; Gervais, V; Page, V; Gonneaud, J; Ayranci, G; Pascoal, TA.; Desautels, R; Benbouhoud, F; Saint-Fort, EF; Verfaillie, SCJ.; Farzin, S; Salaciak, A; Tullo, S; Vachon-Presseau, E; Daoust, LA; Kobe, T; Spreng, N; McSweeney, M; Nilsson, N; Pishnamazi, M; Bedetti, C. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease. BIOLOGICAL PSYCHIATRY; 2021 Apr 15;89(8):776-785. DOI(10.1016/j.biopsych.2020.01.023). [IF=13.382] §H2
6. Park, S; Oh, M; Kim, J; Lee, JH; Yoon, Y; Roh, JH*. F-18-THK-5351, Fluorodeoxyglucose, and Florbetaben PET Images in Atypical Alzheimer's Disease: A Pictorial Insight into Disease Pathophysiology BRAIN SCIENCES; 2021 Apr 6;11(4):465. DOI(10.3390/brainsci11040465), (*corresponding author).
7. Oh, M; Oh, SJ; Lee, SJ; Oh, JS; Roh, JH; Chung, SJ; Lee, JH; Lee, CS; Kim, JS. Clinical Evaluation of(18)F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With(18)F-THK-5351. CLINICAL NUCLEAR MEDICINE; 2020 Nov;45(11):841-847. DOI(dx.doi.org/10.1097/rlu.0000000000003261). [IF=7.794] §H2
8. Barthelemy, NR; Li, Y; Joseph-Mathurin, N; Gordon, BA.; Hassenstab, J; Benzinger, TLS.; Buckles, V; Fagan, A M; Perrin, RJ.; Goate, AM.; Morris, JC.; Karch, CM.; Xiong, C; Allegri, R; Mendez, PC; Berman, SB.; Ikeuchi, T; Mori, H; Shimada, H; Shoji, M; Suzuki, K; Noble, J; Farlow, M; Chhatwal, J; Graff-Radford, NR.; Salloway, S; Schofield, PR.; Masters, CL.; Martins, RN.; O’Connor, A; Fox, NC.; Levin, J; Jucker, M; Gabelle,A; Lehmann, S; Sato, C; Bateman, RJ.; McDade, E; Dominantly Inherited Alzheimer Network (DIAN*). A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. NATURE MEDICINE; 2020 Mar;26(3):398-407; DOI(dx.doi.org/10.1038/s41591-020-0781-z). (*DIAN Consortium authorship†). [IF=53.440] §H1
9. Son, HJ; Oh, JS; Oh, M; Kim, SJ; Lee, JH; Roh, JH*; Kim, JS*. The clinical feasibility of deep learning-based classification of amyloid PET images in visually equivocal cases. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; 2020 Feb;47(2):332-341. DOI(dx.doi.org/10.1007/s00259-019-04595-y). (*co-corresponding author). [IF=9.236] §H2
10. Suh, CH; Shim, H; Kim, SJ; Roh, JH; Lee, JH; Kim, MJ; Park, S; Jung, W; Sung, J; Jahng, GH. Alzheimer's Dis Neuroimaging Development and Validation of a Deep Learning-Based Automatic Brain Segmentation and Classification Algorithm for Alzheimer Disease Using 3D T1-Weighted Volumetric Images. AMERICAN JOURNAL OF NEURORADIOLOGY; 2020 Dec;41(12):2227-2234. DOI(10.3174/ajnr.A6848).
11. 8 Li, L; Kim, HJ; Roh, JH; Kim, M; Koh, W; Kim, Y; Heo, H; Chung, JH; Nakanishi, M; Yoon, T; Hong, CP; Seo, SW; Na, DL; Song, JW. Pathological manifestation of the induced pluripotent stem cell-derived cortical neurons from an early-onset Alzheimer's disease patient carrying a presenilin-1 mutation (S170F). CELL PROLIFERATION; 2020 Apr;53(4):e12798. DOI(10.1111/cpr.12798).
12. Lee, YB; Yoo, K; Roh, JH; Moon, WJ; Jeong, Y. Brain-State Extraction Algorithm Based on the State Transition (BEST): A Dynamic Functional Brain Network Analysis in fMRI Study. BRAIN TOPOGRAPHY; 2019 Sep;32(5):897-913. DOI(10.1007/s10548-019-00719-7).
13. Kim, HR; Lee, P; Seo, SW; Roh, JH; Oh, M; Oh, JS; Oh, SJ; Kim, JS; Jeong, Y. Comparison of Amyloid beta and Tau Spread Models in Alzheimer's Disease. CEREBRAL CORTEX; 2019 Sep 13;29(10):4291-4302. DOI(10.1093/cercor/bhy311).
14. Dube, Umber; Del-Aguila, Jorge L; Li, Zeran; Budde, John P; Jiang, Shan; Hsu, Simon; Ibanez, Laura; Fernandez, Maria Victoria; Farias, Fabiana; Norton, Joanne; Gentsch, Jen; Wang, Fengxian; Salloway, Stephen; Masters, Colin L; Lee, Jae-Hong; Graff-Radford, Neill R; Chhatwal, Jasmeer P; Bateman, Randall J; Morris, John C; Karch, Celeste M; Harari, Oscar; Cruchaga, Carlos; Dominantly Inherited Alzheimer Network (DIAN*). An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. NATURE NEUROSCIENCE; 2019 Nov;22(11):1903-1912. DOI(10.1038/s41593-019-0501-5). (*DIAN Consortium authorship†). [IF=24.884] §H2
15. Li, L*; Roh, JH*; Kim, HJ; Park, HJ; Kim, M; Koh, W; Heo, H; Chang, JW; Nakanishi, M; Yoon, T; Na, DL; Song, J. The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction. EXPERIMENTAL NEUROBIOLOGY; 2019 Jun;28(3):329-336. DOI(10.5607/en.2019.28.3.329). (*contributed equally to this manuscript).
16. Kim, JE; Park, SH; Hong, YJ; Hwang, J; Han, NE; Lee, SM; Roh, JH; Kim, JS; Lee, JH. Qualitative Comparison of Semantic Memory Impairment in Patients with Amnestic Mild Cognitive Impairment Based on beta-Amyloid Status. JOURNAL OF CLINICAL NEUROLOGY; 2019 Jan;15(1):27-37. DOI(10.3988/jcn.2019.15.1.27).
17. Lee, DH; Lee, P; Seo, SW; Roh, JH; Oh, M; Oh, JS; Oh, SJ; Kim, JS; Jeong, Y. Neural substrates of cognitive reserve in Alzheimer's disease spectrum and normal aging. NEUROIMAGE; 2019 Feb 1;186:690-702. DOI(10.1016/j.neuroimage.2018.11.053). [IF=6.556] §H1
18. Son, HJ; Oh, JS; Roh, JH; Seo, SW; Oh, M; Lee, SJ; Oh, SJ; Kim, JS. Differences in gray and white matter F-18-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; 2019 Feb;46(2):357-366. DOI(10.1007/s00259-018-4125-x). [IF=9.236] §H2
19. Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Graber, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Voglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph; Schofield, Peter R.; Rossor, Martin N.; Graff-Radford, Neill R.; Salloway, Stephen; Ghetti, Bernardino; Ringman, John M.; Noble, James M.; Chhatwal, Jasmeer; Goate, Alison M.; Benzinger, Tammie L. S.; Morris, John C.; Bateman, Randall J.; Wang, Guoqiao; Fagan, Anne M.; McDade, Eric M.; Gordon, Brian A.; Jucker, Mathias; Dominantly Inherited Alzheimer Network (DIAN*). Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease. NATURE MEDICINE; 2019 Feb;25(2):277-283. DOI(10.1038/s41591-018-0304-3). [IF=53.440] §H1
20. Park, JE; Yun, J; Kim, SJ; Shim, WH; Oh, JS; Oh, M; Roh, JH; Seo, SW; Oh, SJ; Kim, JS. Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer's disease differ according to disease severity and amyloid positivity. PLOS ONE; 2019 Dec 13;14(12):e0226265. DOI(10.1371/journal.pone.0226265).
21. Kim, Y*; Yoo, YK*; Kim, HY*; Roh, JH*; Kim, J; Baek, S; Lee, JC; Kim, HJ; Chae, MS; Jeong, D; Park, D; Lee, S; Jang, H; Kim, K; Lee, JH; Byun, BH; Park, SY; Ha, JH; Lee, KC; Cho, WW; Kim, JS; Koh, JY; Lim, SM; Hwang, KS*. Comparative analyses of plasma amyloid-beta levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system. SCIENCE ADVANCES; 2019 Apr 17;5(4):eaav1388. DOI(10.1126/sciadv.aav1388). (*contributed equally to this manuscript). [IF=14.136] §H2
22. Li, L*; Roh, JH*; Chang, EH; Lee, Y; Lee, S; Kim, M; Koh, W; Chang, JW; Kim, HJ; Nakanishi, M; Barker, RA; Na, DL; Song, J. iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia. EXPERIMENTAL NEUROBIOLOGY; 2018 Oct;27(5):350-364. DOI(10.5607/en.2018.27.5.350). (*contributed equally to this manuscript).
23. Kim, EJ; Kim, YE; Jang, JH; Cho, EH; Na, DL; Seo, SW; Jung, NY; Jeong, JH; Kwon, JC; Park, KH; Park, KW; Lee, JH; Roh, JH; Kim, HJ; Yoon, SJ; Choi, SH; Jang, JW; Ki, CS; Kim, SH. Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia. NEUROBIOLOGY OF AGING; 2018 Dec;72:186.e1-186.e7. DOI(10.1016/j.neurobiolaging.2018.06.031).
24. Chung, J; Yoo, K; Lee, P; Kim, CM; Roh, JH; Park, JE; Kim, SJ; Seo, SW; Shin, JH; Seong, JK; Jeong, Y. Normalization of cortical thickness measurements across different T1 magnetic resonance imaging protocols by novel W-Score standardization. NEUROIMAGE; 2017 Oct 1;159:224-235. DOI(10.1016/j.neuroimage.2017.07.053). [IF=6.556] §H1
25. Park, JE; Park, B; Kim, SJ; Kim, HS; Choi, CG; Jung, SC; Oh, JY; Lee, JH; Roh, JH; Shim, WH. Alzheimer's Dis Neuroimaging Initiative (ADNI). Improved Diagnostic Accuracy of Alzheimer's Disease by Combining Regional Cortical Thickness and Default Mode Network Functional Connectivity: Validated in the Alzheimer's Disease Neuroimaging Initiative Set. KOREAN JOURNAL OF RADIOLOGY; Nov-Dec 2017;18(6):983-991. DOI(10.3348/kjr.2017.18.6.983).
26. Chae, MS; Kim, J; Jeong, D; Kim, Y; Roh, JH; Lee, SM; Heo, Y; Kang, JY; Lee, JH; Yoon, DS; Kim, TG; Chang, ST; Hwang, KS. Enhancing surface functionality of reduced graphene oxide biosensors by oxygen plasma treatment for Alzheimer's disease diagnosis. BIOSENSORS & BIOELECTRONICS; 2017 Jun 15;92:610-617. DOI(10.1016/j.bios.2016.10.049). [IF=10.618] §H2
27. Hong, YJ; Kim, CM; Kim, JE; Roh, JH; Kim, JS; Seo, SW; Na, DL; Lee, JH. Regional amyloid burden and lacune in pure subcortical vascular cognitive impairment. NEUROBIOLOGY OF AGING; 2017 Jul;55:20-26. DOI(10.1016/j.neurobiolaging.2017.03.010).
28. Kim, GH; Seo, SW; Jung, K; Kwon, OH; Kwon, H; Kim, JH; Roh, JH; Kim, MJ; Lee, BH; Yoon, DS; Hwang, JW; Lee, JM; Jeong, JH; You, H; Heilman, KM; Na, DL. The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment. JOURNAL OF NEUROLOGY; 2016 Jan;263(1):89-99. DOI(10.1007/s00415-015-7946-6).
29. Hong, YJ; Kim, CM; Jang, EH; Hwang, J; Roh, JH*; Lee, JH*. White Matter Changes May Precede Gray Matter Loss in Elderly with Subjective Memory Impairment. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; 2016;42(3-4):227-235. DOI(10.1159/000450749). (*co-corresponding author).
30. Hong, YJ; Jang, EH; Hwang, J; Roh, JH; Kwon, M; Lee, D; Lee, JH. Effect of Midazolam on Memory During Fiberoptic Gastroscopy Under Conscious Sedation. CLINICAL NEUROPHARMACOLOGY; Mar-Apr 2015;38(2):47-51. DOI(10.1097/WNF.0000000000000067).
31. Park, SA; Kang, JH; Kang, ES; Ki, CS; Roh, JH; Youn, YC; Kim, SY; Kim, SY. A Consensus in Korea Regarding a Protocol to Reduce Preanalytical Sources of Variability in the Measurement of the Cerebrospinal Fluid Biomarkers of Alzheimer's Disease. JOURNAL OF CLINICAL NEUROLOGY; 2015 Apr;11(2):132-41. DOI(10.3988/jcn.2015.11.2.132).
32. Hong, YJ; Jang, EH; Hwang, J; Roh, JH; Lee, JH. The Efficacy of Cognitive Intervention Programs for Mild Cognitive Impairment: A Systematic Review. CURRENT ALZHEIMER RESEARCH; 2015;12(6):527-42. DOI(10.2174/1567205012666150530201636).
33. Kim, CM; Hwang, J; Lee, JM; Roh, JH*; Lee, JH*; Koh, JY; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Amyloid Beta-Weighted Cortical Thickness: A New Imaging Biomarker in Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH; 2015;12(6):563-71. DOI(10.2174/1567205012666150530202124). (*co-corresponding author).
34. Roh, JH; Lee, JH. Recent Updates on Subcortical Ischemic Vascular Dementia. JOURNAL OF STROKE; 2014 Jan;16(1):18-26. DOI(10.5853/jos.2014.16.1.18).
35. Roh, JH; Jiang, H; Finn, MB; Stewart, FR; Mahan, TE; Cirrito, JR; Heda, A; Snider, BJ; Li, MJ; Yanagisawa, M; de Lecea, L; Holtzman, DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. JOURNAL OF EXPERIMENTAL MEDICINE; 2014 Dec 15;211(13):2487-96. DOI(10.1084/jem.20141788). [IF=14.307] §H2
36. Dalal, J*; Roh, JH*; Maloney, SE; Akuffo, A; Shah, S; Yuan, H; Wamsley, B; Jones, WB; Strong, CD; Gray, PA; Holtzman, DM; Heintz, N; Dougherty, JD. Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. GENES & DEVELOPMENT; 2013 Mar 1;27(5):565-78. DOI(10.1101/gad.207654.112). (*contributed equally to this manuscript). [IF=11.361] §H2
37. Yoon, CW; Seo, SW; Park, JS; Kwak, KC; Yoon, U; Suh, MK; Kim, GH; Shin, JS; Kim, CH; Noh, Y; Cho, H; Kim, MJ; Kim, JH; Roh, JH; Lee, JM; Na, DL. Cerebellar Atrophy in Patients with Subcortical-Type Vascular Cognitive Impairment. CEREBELLUM; 2013 Feb;12(1):35-42. DOI(10.1007/s12311-012-0388-0).
38. Musiek, ES; Lim, MM; Yang, GR; Bauer, AQ; Oi, L; Lee, Y; Roh, JH; Ortiz-Gonzalez, X; Dearborn, JT; Culver, JP; Herzog, ED; Hogenesch, JB; Wozniak, DF; Dikranian, K; Giasson, BI; Weaver, DR; Holtzman, DM; FitzGerald, GA. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration JOURNAL OF CLINICAL INVESTIGATION; 2013 Dec;123(12):5389-400. DOI(10.1172/JCI70317). [IF=14.808] §H2
39. Roh, JH; Huang, YF; Bero, AW; Kasten, T; Stewart, FR; Bateman, RJ; Holtzman, DM. Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-beta in Mice with Alzheimer's Disease Pathology. SCIENCE TRANSLATIONAL MEDICINE; 2012 Sep 5;4(150):150ra122. DOI(10.1126/scitranslmed.3004291). [IF=17.956] §H2
40. Kim, JH; Lee, JW; Kim, GH; Roh, JH; Kim, MJ; Seo, SW; Kim, ST; Jeon, S; Lee, JM; Heilman, KM; Na, DL. Cortical asymmetries in normal, mild cognitive impairment, and Alzheimer's disease. NEUROBIOLOGY OF AGING; 2012 Sep;33(9):1959-66.DOI(10.1016/j.neurobiolaging.2011.06.026).
41. Kim, GH; Jeon, S; Seo, SW; Kim, MJ; Kim, JH; Roh, JH; Shin, JS; Kim, CH; Im, K; Lee, JM; Qiu, AQ; Kim, ST; Na, DL. Topography of cortical thinning areas associated with hippocampal atrophy (HA) in patients with Alzheimer's disease (AD). ARCHIVES OF GERONTOLOGY AND GERIATRICS; Mar-Apr 2012;54(2):e122-9. DOI(10.1016/j.archger.2011.10.013).
42. Seo, SW; Lee, JH; Jang, SM; Kim, ST; Chin, J; Kim, GH; Kim, JH; Roh, JH; Kim, MJ; Kim, SH; Na, DL. Neurochemical alterations of the entorhinal cortex in amnestic mild cognitive impairment (aMCI): A three-year follow-up study. ARCHIVES OF GERONTOLOGY AND GERIATRICS; Jan-Feb 2012;54(1):192-6. DOI(10.1016/j.archger.2011.04.002).
43. Roh, JH; Holtzman, DM. Stealth Attack: Plaque-Specific Antibody Allows for Efficient A beta Removal without Side Effects. NEURON; 2012 Dec 6;76(5):859-61. DOI(10.1016/j.neuron.2012.11.018). [IF=17.173] §H2
44. Seo, SW; Lee, JM; Im, K; Park, JS; Kim, SH; Kim, ST; Ahn, JH; Kim, MJ; Kim, GH; Kim, JH; Roh, JH; Cheong, HK; Na, DL. Cardiovascular Risk Factors Cause Cortical Thinning in Cognitively Impaired Patients Relationships Among Cardiovascular Risk Factors, White Matter Hyperintensities, and Cortical Atrophy. ALZHEIMER DISEASE & ASSOCIATED DISORDERS; Apr-Jun 2012;26(2):106-12. DOI(10.1097/WAD.0b013e31822e0831).
45. Roh, JH; Park, MH; Ko, D; Park, KW; Lee, DH; Han, C; Jo, SA; Yang, KS; Jung, KY . Region and frequency specific changes of spectral power in Alzheimer's disease and mild cognitive impairment. CLINICAL NEUROPHYSIOLOGY; 2011 Nov;122(11):2169-76. DOI(10.1016/j.clinph.2011.03.023).
46. Roh, JH; Qiu, AQ; Seo, SW; Soon, HW; Kim, JH; Kim, GH; Kim, MJ; Lee, JM; Na, DL. Volume reduction in subcortical regions according to severity of Alzheimer's disease. JOURNAL OF NEUROLOGY; 2011 Jun;258(6):1013-20. DOI(10.1007/s00415-010-5872-1).
47. Bero, AW; Yan, P; Roh, JH; Cirrito, JR; Stewart, FR; Raichle, ME; Lee, JM; Holtzman, DM. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. NATURE NEUROSCIENCE; 2011 Jun;14(6):750-6. DOI(10.1038/nn.2801). [IF=24.884] §H2
48. Kim, MJ; Im, K; Lee, JM; Park, A; Chin, J; Kim, GH; Kim, JH; Roh, JH; Seo, SW; Na, DL. Cortical Thinning in Verbal, Visual, and Both Memory-predominant Mild Cognitive Impairment. ALZHEIMER DISEASE & ASSOCIATED DISORDERS; Jul-Sep 2011;25(3):242-9. DOI(10.1097/WAD.0b013e3182076d31).
49. Roh, JH; Kim, JB; Seo, HS; Kwon, DY; Park, MH. Teaching NeuroImages: Posterior cerebral artery susceptibility vessel sign on T2*-weighted gradient echo imaging. NEUROLOGY; 2011 Jul 26;77(4):e25. DOI(10.1212/WNL.0b013e3182267b60). [IF=9.910] §H2
50. Roh, JH; Suh, MK; Kim, EJ; Go, SM; Na, DL; Seo, SW. GLUCOSE METABOLISM IN PROGRESSIVE NONFLUENT APHASIA WITH AND WITHOUT PARKINSONISM. NEUROLOGY; 2010 Sep 14;75(11):1022-4. DOI(10.1212/WNL.0b013e3181f25ebb). [IF=9.910] §H2
51. Seok, HY; Eun, MY; Choi, JY; Roh, JH; Park, MH; Park, KW; Kwon, DY. Atypical Spontaneous Intracranial Hypotension With a Head-Shaking Headache. HEADACHE ; 2010 Jul;50(7):1211-4. DOI(10.1111/j.1526-4610.2010.01704.x).
52. Lyu, I; Seong, JK; Shin, SY; Im, K; Roh, JH; Kim, MJ; Kim, GH; Kim, JH; Evans, AC; Na, DL; Lee, JM. Spectral-based automatic labeling and refining of human cortical sulcal curves using expert-provided examples. NEUROIMAGE; 2010 Aug 1;52(1):142-57. DOI(10.1016/j.neuroimage.2010.03.076). [IF=6.556] §H1
53. Roh, JH; Kim, BJ; Jang, JH; Seo, WK; Lee, SH; Kim, JH; Oh, K; Park, KW; Lee, DH; Koh, SB. The relationship of pain and health-related quality of life in Korean patients with Parkinson's disease. ACTA NEUROLOGICA SCANDINAVICA; 2009 Jun;119(6):397-403. DOI(10.1111/j.1600-0404.2008.01114.x).
54. Roh, JH; Kim, JH; Oh, K; Kim, SG; Park, KW; Kim, BJ. Cortical Laminar Necrosis Caused by Rapidly Corrected Hyponatremia. JOURNAL OF NEUROIMAGING; 2009 Apr;19(2):185-7. DOI(10.1111/j.1552-6569.2008.00244.x).
55. Koh, SB; Roh, JH; Kim, JH; Oh, K; Kim, BJ; Kim, GS; Park, BK; Kim, SJ; Yoon, JS. Ultrasonographic findings of shoulder disorders in patients with Parkinson's disease. MOVEMENT DISORDERS; 2008 Sep 15;23(12):1772-6. DOI(10.1002/mds.22191). [IF=10.338] §H2
56. Roh, JH; Park, KW; Kim, BJ. Deep gray matter lesion caused by hypoglycemia. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION; 2008 Mar;87(3):249-50. DOI(10.1097/PHM.0b013e318164a950).
57. Roh, JH; Koo, YS; Jang, SH; Park, MH. Medulla compression caused by vertebral artery dolichoectasia. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY; 2008 Feb;79(2):222. DOI(10.1136/jnnp.2007.123885). [IF=10.154] §H2
58. Roh, JH; Kim, JH; Koo, Y; Seo, WK; Lee, JM; Lee, YH; Park, MH. Teaching NeuroImage: Diverse MRI signal intensities with Wernicke encephalopathy. NEUROLOGY; 2018 Aug;57(8):1039-1053. DOI(10.1212/01.wnl.0000308951.21103.49). [IF=9.910] §H2
59. Kim, JH; Roh, JH; Koh, SB. Reversible injury of internal capsule and splenium in a patient with transient hypoglycemic hemiparesis. CEREBROVASCULAR DISEASES; 2006;22(4):282-3.DOI(10.1159/000094330).
60. Roh, JH; Koh, SB; Kim, JH. Orbital myositis in Behcet's disease: A case report with MRI findings. EUROPEAN NEUROLOGY; 2006;56(1):44-5. DOI(10.1159/000095142).
†DIAN Consortium Authorship: Consortia authorship. If a consortium is listed as a collective of authors, all members of the consortium are considered authors and must be listed in the published article as such. (https://www.nature.com/nature-research/editorial-policies/authorship).
Lab Intro
Research Topics: Alzheimer’s disease, Neurodegenerative disorders, Sleep, Aging
Dr. Jee Hoon Roh is a trained neurologist and has worked on basic and translational research in Alzheimer’s disease (AD) and neurodegenerative disorders. Dr. Roh has published several leading papers on how sleep or brain neuronal activities affect the amyloid beta metabolism in the brain with Dr. David M. Holtzman at Washington University. He has now extended the findings in humans using in vivo pathology PET images and sleep monitoring. Dr. Roh also pioneered in blood-based biomarkers of AD in collaboration with several leading groups in the field. Dominantly Inherited Alzheimer Network (DIAN)-Korea and senescence-associated research are among the major works that Dr. Roh is actively engaged in.
Etc.
PATENTS
International
1. Diagnostic Kit for Diagnosis of Alzheimer’s Disease Using Dissociation of Protein Aggregates/Europe/2019/EP2990801B1
2. Diagnostic Kit for Diagnosis of Abnormal Protein Aggregation- or Misfolding-Related Diseases Using Dissociation of Protein Aggregates/USA/2018/US10006920B2
3.タンパク質凝集?の溶解を用いたタンパク質の非正常な凝集またはミスフォ?ルディングと?連した疾患または疾病を診?する診?キット/Japan/2017/JP6189526B2

Domestic
1. 체내 단백질 응집체의 용해를 이용한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 혈액진단키트/대한민국/2016.05.02/10-1619238-0000
2. 혈액 중 단백질 응집체의 용해를 통한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 진단키트/대한민국/2016.05.11/10-1621935-0000
3. 퇴행성 뇌질환 진단에 적합한 이미지 바이오 마커를 획득하는 방법, 장치 및 이를 이용하여 퇴행성 뇌질환을 진단하는 방법/대한민국/2017/10-1696061-0000

BOOKS
Gene Therapy in Neurological Disorders. ELSEVIER (Academic Press), 2018. ISBN 978-0128098134. Chapter 7. Lentiviral Vector Delivery of Orexin Gene to Study Potential Role of Orexin and Sleep Modulation in the Pathogenesis of Alzheimer's Disease.
Dementia Cases. 뇌미인, 2016. ISBN 979-11-956781-6-7. Chapter 6. Alzheimer's Disease (Familial Alzheimer's Disease); Chapter 7. Vascular Dementia (Multi-Infarct Dementia); Chapter 23. Treatable Dementia (Neurosyphilis); Chapter 28. Treatable Dementia (Wernicke's Encephalopathy).

AWARDS
2011 Clinical Research Training Fellowship, American Academy of Neurology
2012 Julius Axelrod Travel Award (NINDS), Society for Neuroscience
2012 Postdoctoral Fellow Award in North America, Association of Korean Neuroscientists
2013 Future Medical Investigator Award, LG Life Science
2013 Young Investigator Award, Seoul Medical Association

GRANTS
1. New Therapeutic Target in Alzheimer’s Disease: The Sleep-Wake Cycle* / American Academy of Neurology (AAN) and American Brain Foundation / Clinical Research Training Fellowship / 2011-2013
*The first Korean recipient of the Clinical Research Training Fellowship from the AAN.
2. 알츠하이머병 동물 모델에서 수면 각성 주기와 오렉신 조절을 통한 아밀로이드 베타 병리 치료 효과 / 한국연구재단 / 신진연구자지원사업(장비지원) / 2013-2016
3. 병리진단에 근접한 알츠하이머병 진단 및 바이오 센서 기반 치매 예측 모델 제시 /
보건복지부 / 치매극복기술개발사업 / 2014-2019
4. 한국형 상염색체 우성 알츠하이머병 네트워크 구축 / 보건복지부 / 치매극복기술개발사업 / 2014-2019
5. 다중영상기반 치매 조기진단 및 예측 융합임상기술 개발 / 보건복지부 / 치매극복기술개발사업 / 2014-2019
6. 알츠하이머성 경도인지장애 진단 시스템 개발 / 산업통상자원부 / 산업핵심기술개발사업 / 2015-2018
7. 퇴행성뇌질환 진단 및 치료를 위한 마이크로바이옴 분석 기반 한-스위스 국제협력 연구 / 보건복지부 / 보건의료기술교류 / 2021-2022
8. DIAN 바이오마커 기반 인지예비능 분석 / 보건복지부 / 치매극복연구개발 / 2021-2023
9. 세포 노화 조절을 통한 알츠하이머병 핵심병리 변화 분석 / 한국연구재단 / 창의도전연구 / 2021-2023

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