Expected to stimulate research on the features of CAS and its effective treatments
Category Research
Writer 행정부서 (11) 윤정진
Date Modified Date : 2022.01.26
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Research Team Led by Professors Deok-Woo Kim and Hi-Jin You Establishes Human Cutaneous Angiosarcoma Cell Lines Having In Vivo Tumorigenic Potential

Expected to stimulate research on the features of CAS and its effective treatments

A research team led by professors Deok-Woo Kim and Hi-Jin You from the Department of Plastic and Reconstructive Surgery at Korea University Ansan Hospital established cutaneous angiosarcoma (CAS) cell lines having in vivo tumorigenic potential for the first time.

Cutaneous angiosarcoma (CAS) is a rare soft tissue malignant cancer with dismal prognosis. Even though this disease follows an aggressive course with propensity for local relapse and metastasis, the biological properties are not well understood and a standard treatment protocol has not been established. Its low incidence has led to a lack of experimental studies let alone large randomized controlled clinical trials. Cell lines provide a pure population of cells through a subculture, which is valuable for R&D because it provides a consistent sample of genotype or phenotype. To date, only three human CAS cell lines - ISO-HAS, AS-M, and HAMON - have been reported. However, researchers have faced limitations in using them as they have very weak tumorigenesis, if any, in vivo.

In this study, researchers established two new CAS cell lines - KU-CAS3 and KU-CAS5 ­- and they were confirmed to have endothelial properties and tumorigenic potential. These new cell lines are expected to make a significant contribution to research on the features of CAS and its effective treatments. The team is currently conducting subsequent follow-up research.

The research has been published in the January 2022 issue of the internationally recognized SCI-indexed journal Head & Neck: Journal of the Sciences and Specialties of the Head and Neck, and the research team is flooded with inquiries from other CAS research teams from all around the world who are interested in using the cell lines for their studies.