고려대학교 의과대학 및 의과학연구지원센터 구성원이 아닌 경우에는 본인인증을 통하여 글을 작성할 수 있습니다.
- 본인인증 후 글을 작성할 수 있습니다.
내 명의의 휴대전화로 비밀번호를 재설정 할 수 있습니다.
Dean invites you, KUMED Internationals!
Korea University College of Medicine successfully completed Deans’ Luncheon for KU Medicine Internationals with the participation of 90 people from 21 countries at the cafe lounge at the main building of Korea University College of Medicine at noon on Aug. 25.
More than 30 students of college of medicine from many countries including the US, UK, Germany, Spain, Turkey and Hong Kong have visited Korea University College of Medicine for clinical clerkship and the number of foreign researchers, research professors and fellows visiting Korea University Anam, Guro and Ansan Hospitals as well as graduate school have increased. As such, the international standing of Korea University College of Medicine increasing as time goes on. The Korea University College of Medicine organized this event to promote networking and sharing opinion with foreign visitors who are staying at the College of Medicine and hospitals.
The event started with the opening event followed by watching video clip on the Korea University Medical Center, welcome remarks by the dean of College of Medicine, encouragement remarks by president of Anam Hospital, introduction of participants, listening to the talks of foreign participants and taking a group photo. The atmosphere of the event was comfortable as the participants enjoyed various kinds of food and dialogues.
Participants had a good time by sharing their own episode and stories related to practice and had a meaningful moment by talking various topics with an academic advisor. A participant from Spain said “I learned how to understand and respect cultural diversity by working as a fellow in Korea”. “I’d like to thank my advisor and very pleased to meet friends from many countries as I could not spend much time with them to focus on my work,” he added.
Presenting more effective cancer treatment strategy than before
Professor Tae Woo Kim of Department of Biomedical Sciences revealed that the combined therapy of a cancer immunotherapy with an epigenetic inhibitor is more effective in immune-refractory cancer treatment.
Cancer immunoediting drives the adaptation of tumor cells to host immune surveillance and at the same time the acquisition of resistance to cancer immunotherapy. Recently, the research team found that immunoediting driven by antigen-specific T cells enriches NANOG, which coordinates and controls the embryonic stem cells to be developed into a certain organ, expression in tumor cells. It is found that NANOG is a major factor that controls the immunoediting for enrichment of cancer stem cells which are resistance to cancer immunotherapy.
In addition, it is identified that HDAC1 which is an epigenetic control factor plays an essential role in obtaining malicious expression type of immunoedited cancers. In addition, the team presented that applying both cancer immunotherapeutic agents and epigenetic inhibitors at the same time could be an effective cancer treatment strategy upon dealing with malicious cancer with high NANOG expression.
In recognition of this study, the paper was published in Cancer Research under the title of ‘HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells’ in last Nov.
Korea University Medical Center, Opening the Door of Future Medicine
Starting the construction of state-of-the-art Medical Applied R&D Global Initiative Center, leaping forward through the 4th industrial revolution of the medical sector
Korea University Medical Center started the construction of state-of-the-art Medical Applied R&D Global Initiative Center in earnest with the ground breaking ceremony of the center on Sep. 26. The new hospital, which will serve as a new driving engine for Korea University Medical Center is expected to be the hub to maximize the clinical and research capabilities of the hospital and bring about new paradigm in the medical sector under the motto of ‘Realization of the 4th industrial revolution in the medical sector’. The goal of the convergence medicine center is to realize future-oriented hospital that provides optimized and customized care to patients with serious diseases and establish the industrialization of medicine and virtuous cycle investment structure through research to emerge as a world-class medical center.
The state-of-the-art Medical Applied R&D Global Initiative Center is planned to be completed in 2022 with the scale of 130,000㎡ in total area. The facilities for care will be completed first to make a center specialized cancer, heart and nerve diseases. We plan to focus on improving the quality of care. In addition, treatment and research capabilities of three hospitals under Korea University Medical Center will be integrated into the convergence R&D center to establish the best infrastructure in Korea that can lead the medical research.
If the construction is completed, medical service based on precision medicine will be realized for the first time in Korea and the possibility of treating incurable diseases and serious cancers will be increased a step higher. In addition, the center will have A.I-Driven Hospital where A.I. is fully used and developed to make the best medical system that can provide accurate diagnosis and optimal treatment for patients. It will position itself as the model of a future hospital and mecca of the 4th industry, which collects medical information of patients and other data including genetic information and applies the information to patient care.
Development of a new technology that manipulate neurons involved in a specific behavior
A team led by professor Dongmin Lee at Department of Anatomy developed a new optigenetics technology that identifies the relationship between neurons and specific behavior using light.
The process of thinking in our brain and linkage between the thought and behavior has not been revealed. Despite recent advances in optogenetics to manipulate cells in tissues with light, it has been difficult to develop the technology that controls the neuron that induces a certain behavior in a selective manner.
The “genetically encoded calcium indicator” technology, which was widely used in the present, measures the activation of cells by tracking changes in calcium concentration caused by neuronal activation. However, the technology had a limitation as the area for monitoring is limited and activated cells cannot be controlled secondarily.
Cal-Light (Calcium and Light-Induced Gene Handling Toolkit) developed by the team led by professor Dongmin Lee overcame the shortcomings of the existing technology to develop a technology to drive expression of gene in an activated neuron by recognizing both blue light and calcium concentration. If a photoreactive opsin is used as a reporter, we can manipulate activated neurons selectively.
By taking the idea from these characteristics, the research team made the lab mice learn into which Cal-Light was injected to receive compensation for lever-pressing behavior and injected lube right when the mice pressed the lever for the purpose of expressing a protein called halorhodopsin in the motor neuron. Halorhodopsion, which responds to yellow right, suppresses neuron and is expressed only by lever pressing behavior by Cal-Light system. The result showed that the lever pressing behavior was inhibited selectively when the yellow light was brought onto the lab mice. On the contrary, if the yellow was not brought after one day, the lab mice started pressing the lever.
As the test result shows, it becomes possible to manipulate a specific behavior by expressing optogenetic protein in neuronal ensembles utilizing Cal-Light. It is possible to control and observe the activities of neurons in tissues and even in freely moving animals and analyze the effect of neuron activity control.
The result of the study was recognized in its excellence to the extent that it is published in the international journal Nature Biotechnology of Nature under the title of in last Sept.
Professor Dongmin Lee said “Cal-Light presented a new way to study the direct relationship between cells and behavior, which has face difficulties in the previous research”. “The ultimate goal is to develop technology for the treatment of neuropsychiatric diseases such as dementia, disorder related to memory, epilepsy, depression and obsessive compulsive disorder”, he added.