고려대학교 의과대학 및 의과학연구지원센터 구성원이 아닌 경우에는 본인인증을 통하여 글을 작성할 수 있습니다.
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내 명의의 휴대전화로 비밀번호를 재설정 할 수 있습니다.
The 2019 World Federation for Medical Education World Conference (WFME 2019) was successfully held in Seoul, Korea.
The WFME 2019 was the first and the largest international conference of medical education held in Korea, attracting 800 participants from 56 countries around the world.
The conference provided a meaningful opportunity for exchanging ideas about the future of medical education.
The 2019 World Federation for Medical Education World Conference (WFME 2019) was successfully held in Seoul, co-hosted by Korea University College of Medicine (Dean Hong Sik Lee) and the Korean Council on Medical Education (President Hee Chul Han).
The WFME 2019 was held in the Grand Walkerhill Seoul from April 7th to 10th, joined by 800 experts in medical education and accreditation from 56 countries. The conference program spanned a range of topics including medical education and accreditation for quality assurance, state-run tests and refresher courses in 67 invited lectures and 300 freestyle presentations.
Notably, participants not only shared the current status of medical education in their own countries but discussed the need to establish global standards for medical education, the current records of global accreditation for medical education institutions and future advances in the field, spurred by growing exchanges of medical personnel across countries. In addition, postgraduate medical education that has been rarely touched in the discourse of medical education, i.e., the need for quality improvement and accreditation for medical residency training, was actively discussed in the conference, which was very meaningful considering the reality of residency training in Korea.
Participants also exchanged their ideas on the role of hospitals as training institutions, intensive postgraduate medical education and the improvement options. They agreed that the role of college of medicine needs to be strengthened in the postgraduate medical education as in the US and the UK. Excellent examples were introduced on how to nurture doctors who have deeper understandings of their society and empathy with their patients, drawing a lot of attention from the audience. Moreover, students expressed their own opinions on medical student exchange programs and accreditation for medical education, providing an opportunity to have a grand perspective including views of both providers and consumers of medical education.
The WFME 2019 was very meaningful because it was the first of its kind held in Asia and it provided an opportunity to discuss the goal of current medical education, the limits and issues in different countries from the perspective of followers in medical education, not from the views of advanced runners. Furthermore, the meeting showed that Korea is making efforts to advance medical education based on the global standards free from the existing leadership of advanced countries such as the US and those in Europe, playing a leading role in medical education.
President Hee Chul Han of the Korean Council on Medical Education said "It is a great honor to co-host the WFME World Conference with Korea University College of Medicine in 16 years since the previous one. It is especially meaningful that the 12 members of the Korean Council on Medical Education eagerly cooperated to organize the event including the Korean Medical Association, the Korean Hospital Association, the Korean Academy of Medical Sciences, the Korea Association of Medical Colleges and the Korean Doctors Council." He also added "I hope the government and our society pay attention to our efforts and take measures to promote normalization of medical residency training and advancement of medical education, based on the standards for medical residency training discussed in the WFME 2019."
Prof. Hong Sik Lee, Dean of Korea University College of Medicine, said "It is critical to understand the global trend to advance the medical education in Korea and the government as well as the medical community needs to discuss necessary measures in public about international exchanges of medical students and experts," and he also added "The sustained quality improvement in medical education in Korea requires our society's support and coordination." The Dean finally stated "Above all, I should say that it was a great privilege to host the WFME 2019 for the first time in Asia to discuss the current agenda in medical education with global experts. Korea University College of Medicine will play a leading role in proposing a novel paradigm and setting global standards in medical education to resolve public health issues."
Flubendazole’s anticancer activity and suppression of cancer stem cell properties
The treatment of triple-negative breast cancer (TNBC) remains challenging due to the absence of established molecular targets for the phenotype. These tumors account for 10-15% of all breast cancers and tend to be more aggressive with a higher risk of recurrence and metastasis, leading to poorer clinical outcomes. Evidence from clinical and preclinical studies suggests that the aggressive nature of TNBC may be partially due to the existence of breast cancer stem cells (BCSCs). BCSCs are thought to play a crucial role in promoting tumor initiation, growth and propagation, as well as resistance to chemotherapy.
Prof. Jae Hong Seo's research team in the Department of Hemato-oncology at Korea University Guro Hospital cultivated mammospheres and adherent cells enriched with cancer stem cells using TNBC cell lines, transplanted them into mice respectively, and compared results in tumor growth rate and metastasis. Primary tumors were observed to spread fast to the lungs and the livers of mice grafted with mammospheres, where the ALDH1 activity was higher than in adherent cells, and the metastatic factor STAT3 was activated in the ALDH1+ cell fraction. The study showed that cancer stem cells in TNBC accelerated metastasis and they have a correlation with the STAT3 signaling pathway, a major metastatic factor.
Flubendazole is a widely used anthelmintic agent approved by the FDA and suppresses the multiplication of parasites, faster than normal cells of humans, by acting as a tubulin inhibitor. Though the study of anticancer effects of flubendazole for hematologic malignancy was first published in 2010, there has been no report on the mechanism of its action.
Prof. Jae Hong Seo's research team proposed flubendazole as an agent targeting cancer stem cells and showed reduced cell survival rates and apoptosis in the TNBC cell lines (MDA-MB-231, BT549, HS578T, 4T1) induced by flubendazole. The evidence supporting the mechanism is caspase-3/7 activation and STAT3 suppression. Flubendazole suppressed the expressions of CD24low/CD44high, CD24high/CD49fhigh and ALDH1, which are markers for breast cancer stem cells, through mammoshpere formation. Finally, 4T1 mammospheres were injected into BALB/c mice to prove flubendazole's effects on tumor formation and metastasis by targeting cancer stem cells. Flubendazole significantly inhibited tumor growth as well as lung metastasis induced from primary tumors. In addition, flubendazole also reduced the expressions of STAT3 and Ki-67 in tumor tissues, inducing apoptosis and suppressing cancer stem cell factors.
Therefore, the study showed flubendazole's anticancer effects and inhibition of cancer stem cells in vitro and in vivo, and it suggested flubendazole's potential as a new agent to treat the recurrence and metastasis of TNBC.
pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/29744876
Int J Cancer. 2018 Oct 15;143(8):1978-1993. doi: 10.1002/ijc.31585. Epub 2018 Jul 10.
Romo1 promotes production of reactive oxygen species in tumor cells and development of cancer
Excess amount of reactive oxygen species (ROS) in the body causes diseases such as cancer, diabetes, arthritis and so on. Rising concentration of ROS in the body leads to chronic inflammation and onset of diverse diseases. Mitochondrion is a major cellular organelle generating ROS. Researchers led by Prof. Yoo Young-do in the Graduate School of Medicine at Korea University showed for the first time that a specific protein embedded in the mitochondrial inner membrane promotes generation of ROS and named the protein 'Romo1'. The research team discovered for the first time that Romo1 in mitochondria accelerates production of ROS and development of cancer, and these results will contribute to finding out how to suppress cancer.
Development of new drugs targeting Romo1 requires the knowlege of protein structure of Romo1. However, the existing techniques could not illuminate the protein structure of Romo1 because it is a tiny membrane protein embedded in the inner membrane of mitochondria. The research team used structural bioinformatics to discover the 3D structure of Romo1.
The present study also identified characteristics of Romo1 as a nonselective cation channel in human mitochondria. Moreover, researchers showed that Romo1 is the only protein in the human cell with those features. The 3D structure of Romo1 is expected to be used in developing medicines to treat diseases caused by chronic inflammations.
<Structure of Romo1 embedded in the mitochondrial inner membrane>
pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/29545371
J Cell Biol. 2018 Jun 4;217(6):2059-2071. doi: 10.1083/jcb.201709001. Epub 2018 Mar 15.
Medical students from six countries in Asia shared their experiences in medical research.
Korea University College of Medicine successfully hosted the International Medical Student Research Conference.
The KU International Medical Student Research Conference was held on Nov 9th 2018 at KU College of Medicine.
KU College of Medicine is designing an array of programs to nurture medical students who can actively adapt and play leading roles in a rapidly changing healthcare environment in the era of the 4th Industrial Revolution. The medical student research council has been active since 2010 in helping medical students build their research capabilities through voluntary participation and the nurturing of young medical scientists by offering research opportunities during their undergraduate degrees.
The 9th medical student research council started its activities in December of last year and has 25 research teams with 82 students from the 2nd year premedical course to the 4th year at the college of medicine. The research council has currently carried out medical research with their advisors for a year and has an official opportunity to share their research accomplishments in November. As this year, in particular, marks the 90th anniversary of KU College of Medicine, an international conference was held by inviting medical students from seven medical colleges in five countries such as Hong Kong, Singapore, Japan, Thailand and Taiwan, which have built close relationships with KU.
With about 200 participants including medical students and professors, the conference proceeded in the order of registration, poster presentations, introduction of the medical student research council, oral presentations, discussions, an award ceremony as well as closing remarks. Students from KU College of Medicine took part in 26 poster presentations and 10 oral presentations. Foreign students displayed their research results through four poster presentations and eight oral presentations. Participating students originated from the Chinese University of Hong Kong (CUHK), the University of Hong Kong (HKU), National University of Singapore (NUS), Duke-NUS Medical School, Nagoya University of Japan, Chulalongkorn University of Thailand and National Taiwan University (NTU). Open discussions on the topic of 'medical students' research' yielded many questions and comments from the audience.
Kim Yoon-su, currently in the 2nd year of the premedical course, said "It was quite burdensome for me because every presentation was given in English, while it was a great opportunity for me to meet and share experiences with foreign medical students from diverse countries." Kang Seong-min, currently in his 1st year of the premedical course, said "I was impressed to find that many students are involved in research covering a wide range of topics, and I want to build my research capabilities by participating in the medical student research council." Chatuthanai Savigamin from Chulalongkorn University of Thailand also said "I appreciate KU medical students for presenting me with good memories and I want to build good relationships with them and see them again at international conferences as a doctor.”
Prof. Sun Woong, Head of the Joint Research Program, said "Starting from last year, we have expanded the scope of the existing conference to share outcomes from research. Celebrating the 90th anniversary of the KU College of Medicine this year, it is very meaningful to have a chance to share research experiences with foreign students from leading medical colleges in Asia," he also added "I expect Korean medical students to build their own career as young medical scientists by paving the way in their own research areas."
Lee Hong-sik, Dean of KU College of Medicine stated "We have hosted the International Medical Student Research Conference annually to show students that the process of carrying out research including team work and coordination in a range of environments with a diverse array of cultures is also as critical as getting remarkable research outcomes. He also added "It was a great pleasure to host the international conference led by students and we will promote diverse programs to help medical students grow to be global leading experts in medicine."