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내 명의의 휴대전화로 비밀번호를 재설정 할 수 있습니다.
Successful Hosting of the ‘1st KU-UC Irvine Joint Symposium’
On February 26-27, the Korea University’s College of Medicine (KUCM) successfully hosted a joint two-day academic symposium with the University of California Irvine’s School of Medicine (UCISM).
The goal of the symposium was to discuss five topics that are gaining increasing global attention: Medical Education and Research; Colorectal Surgery; Infectious Diseases; Precision Medicine, and; Circadian Rhythm. Faculty from both Universities presented their latest research and findings, and the venue allowed participating scholars to exchange their scholarly work and views.
Day one of the symposium began with opening remarks from Woong Sun, Associate Dean for Research & Global Engagement, followed by a welcome speech from Dr. Kee Hyoung Lee, Executive Vice President for Medical Affairs of Korea University. Next, there were general introductions of KUCM and UCISM, respectively. The planned sessions proceeded, and ended with closing remarks delivered by Dr. Hong Sik Lee, Dean of KUCM.
Dr. Lee underlined the goal and future prospects of the symposium by saying, “Today’s symposium carries tremendous meaning in that it is the first tangible outcome of the exchanges that began with my predecessor’s visit to UCISM in 2016.” He added, “It is my hope that this symposium will foster closer academic research cooperation between the two schools, so that we may together lead the world’s advancements in medicine. Furthermore, through deeper friendship, I hope that we can continue to contribute to mutual and joint development.”
For each session, the following presenters represented UCISM: Michael J. Stamos, Dean of School of Medicine; Suzanne B. Sandmeyer, Vice Dean for Research; Rozanne Sandri-Goldin, professor of Microbiology; Donal Forthal, professor of Infectious Diseases, and; Paolo Sassone-Corsi, professor of Biochemistry. From KUCM, the following faculty members presented their latest research and findings: Professor Young-Mee Lee of Medical Education & Humanities; Professor Seon-Hahn Kim of Colorectal Surgery; Professor Woo-Joo Kim of Infectious Diseases; Professor Yeol Hong Kim of Oncology & Hematology Department, and; Professor Ki-Hoon Sohn of Forensic Medicine Department.
Day Two delved deeper into the topics presented in each session a day earlier. In addition to the researchers in each area, graduate students and other faculty members who harbor interest in the areas, took part and discussed ways to engage in continued collaborative research.
Dean Lee, explained the significance of the symposium by stating, “KUCM has been exerting efforts to advance joint research in Korea and overseas. As an example, we have been promoting joint studies between the College of Medicine and the College of Engineering, as well as joined the Global Alliance of Medical Excellence, which is a coalition of the world’s 9 top medical schools. This event is more than a simple academic symposium; we have built the foundation that will allow us to continue to engage in exchange with scholars at UCI.” He also expressed the wish to continue this effort by urging, “I hope you will strengthen the exchange between the two schools, and make sizeable contributions to promote joint talent and academic development.”
Professor Serk In Park Uncovers the Biology of Prostate Cancer Spreading to Bone, Shedding a New Light for Late-Stage Prostate Cancer Patients
A c-Met and VEGFR2 dual targeting drug, Cabozantinib, identified to suppress prostate cancer growth in bone and bone destruction
The research team led by Dr. Serk In Park (SI Park), a professor of Biochemistry and Molecular Biology in the College of Medicine at Korea University, succeeded in uncovering the microenvironment of osteoblastic bone metastasis, suggesting a potential new treatment for the late-stage prostate cancer.
Bone metastasis is one of the most fatal clinical problems in the patients with breast, lung and thyroid cancers, which occur in high frequency among Koreans, as well as with prostate cancer, which has also risen sharply in recent years. No effective treatments are available for this condition, and those who suffer from bone metastasis often halt or abandon their therapies because they are considered to be in end-stage of their disease. Despite that breast cancer and prostate cancer have high 5-year survival rates, bone metastasis is especially prominent as the cause of death in these cancers beyond 5 years.
The research team focused their attention on osteoblasts, a type of bone-forming cells, that surrounds the metastatic cancer cells in bone. The team succeeded in delineating how osteoblasts are controlled during the progression of bone metastasis growth and cancer-induced bone destruction. Briefly, the study proved that the hepatocellular growth factors, vascular endothelial cell growth factors, and insulin-like growth factors that are secreted from bone metastasized cancers, activate osteoblasts in the bone metastasis microenvironment. In addition, the team found that by producing osteoclast differentiation factors, these growth factors stimulate tumor growth and osteolysis.
Moreover, the team developed a unique animal test model and cell strain test models to prove that cabozantinib, which is widely used to treat renal cancer, is also effective in suppressing prostate cancer bone metastasis and osteolysis. Because this research brought findings from a clinical observation back in to the test lab, clarifying the biological mechanism at work, it is regarded as an upgrade to previous translational studies, making it a good example of ‘reverse-translational study.’
Professor SI Park claimed, “The findings of this study will contribute to building a treatment system for prostate cancer, the frequency of which has been rising sharply in Korea.” He also emphasized, “Only when there is continuous cooperation and communication between clinical researchers and lab researchers, can we yield clinical tests with strong scientific backing, making the findings significantly more meaningful.”
The findings of the research have been published in the February volume of Cancer Letters, a scholarly journal rated in the top 10% of oncological studies. Entitled, “Dual Targeting c-Met and VEGFR2 in Osteoblasts Suppressed Growth and Osteolysis of Prostate Cancer Bone Metastasis,’ the study was conducted as part of the National Cancer Control System Design Project, sponsored by the National Cancer Center. It was a joint study with Professor Sun-wook Cho of Endocrine & Internal Medicine Department of the Seoul National University Hospital, and Professor Florent Elefteriou of the Vanderbilt Center for Bone Biology at Vanderbilt University.
Professor SI Park completed his D.D..S at Yonsei University, prior to obtaining his master’s degree in Medical Biochemistry from Korea University, and a Ph.D. from the University of Texas M. D. Anderson Cancer Center in U.S.A. He was also a Research Fellow at the University of Michigan their prostate cancer research team. After serving as Assistant Professor for Clinical Pharmacology in the Internal Medicine Department at Vanderbilt University, he has been teaching at Korea University since 2015. His current research is specialized in the interaction of tumors and the bone.
Sentinel Node Mapping Using a Fluorescent Dye and Visible Light During Laparoscopic Gastrectomy for Early Gastric Cancer
Professor Jong-Han Kim (Gastroenterologic Surgery Department, Ansan Hospital) announced the study result that investigate the feasibility of sentinel node mapping using a fluorescent dye and visible light in patients with gastric cancer.
Recently, fluorescent imaging technology using indocyanin green (ICG) and infra-red light offers improved the visibility with the possibility of better sensitivity or accuracy in sentinel node mapping. In our institute, a new fluorescent imaging technique using fluorescein and blue light has been introduced.
Twenty patients with early gastric cancer, for whom laparoscopic distal gastrectomy with standard lymphadenectomy had been planned, were enrolled in this study. Before lymphadenectomy, the patients received a gastrofiberoscopic peritumoral injection of fluorescein solution. The sentinel basin was investigated via laparoscopic fluorescent imaging under blue light (wavelength of 440-490 nm) emitted from an LED curing light. The detection rate and lymph node status were analyzed in the enrolled patients. In addition, short-term clinical outcomes were also investigated.
No hypersensitivity to the dye was identified in any enrolled patients. Sentinel nodes were detected in 19 of 20 enrolled patients (95.0%), and metastatic lymph nodes were found in 2 patients. The latter lymph nodes belonged to the sentinel basin of each patient. Meanwhile, 1patient (5.0%) experienced a postoperative complication that was unrelated to sentinel node mapping. No mortality was recorded among enrolled cases.
Sentinel node mapping with visible light fluorescence was a feasible method for visualizing sentinel nodes in patients with early gastric cancer. In addition, this method is advantageous in terms of visualizing the concrete relationship between the sentinel nodes and surrounding structures.
The study has been published in <ANNALS OF SURGERY>, under the title “Sentinel Node Mapping Using a Fluorescent Dye and Visible Light During Laparoscopic Gastrectomy for Early Gastric Cancer.”
Student Research Group, ‘1st Hoeui Academic Seminar’
On October 30, 2017, the Korea University College of Medicine (KUCM) successfully hosted the 1st Hoeui Academic Seminar.
In an effort to prepare its medical students to become active drivers in the age of the 4th industrial revolution and the rapidly changing medical environment, KUCM has begun preparing a wide variety of programs. One such program focuses on exposing students to medical science research during their undergraduate studies, so that they will be capable of conducting voluntary research. To help develop young medical scientists, since 2011, KUCM has operated a Student Research Group.
The 8th Student Research Group, which initiated its activities in December 2017, is comprised of 17 research teams and 59 students, ranging from 2nd year pre-med students to those in the 4th year of medical school. The teams have been working hard for the past year, with assistance from their academic advisors. Beginning this year, the association meetings were upgraded to allow students to share the finding of their research in an academic seminar setting.
The proceedings of the seminar began with approximately 150 students and professors in attendance. Professor Ho-Sung Son, Associate Dean for Research & Global Outreach, kicked off the seminar with his opening remarks, followed by a special lecture on ‘The Role of Undergraduate Medical School Students in a Research-centered Environment.’ Then, research teams were invited to deliver their findings, for which evaluations were given, before awards were handed out and closing remarks wrapped up the agenda.
Anatomy Professor Hyun-Soo Kim delivered the special lecture. He provided various examples and offered knowhow, while emphasizing the appropriate attitude of medical students as student researchers and effective ways to write an academic paper. Then, 17 research teams took their turns presenting their research findings, which invited a remarkably active student Q&A session, as well as faculty commentaries.
One student who had presented at the seminar expressed satisfaction by reflecting, “for the past year, I was occasionally overwhelmed with both school work and this research activity. But today, I feel happy and proud that all my efforts culminated in this academic seminar.” The student researcher also thanked the faculty advisor for the assistance that was integral to the successful completion of the student research activity, and expressed a new resolve to continue participation in the program, and to expand the research scope in the coming year.
Associate Dean Son expressed his pleasant surprise “to find that students who participated in today’s seminar demonstrated significant caliber in their research as well as in their presentation skills.” He added, “while the 8th Student Research activities may have concluded, they should not stop here. Instead, by identifying their own areas of research interest, I look forward to witnessing their continued growth into young medical scientists.”