기초교실 - 생화학분자생물학교실


손정원 교수

손정원 교수

손정원 / Jeong-Won Sohn

  • 소속생화학분자생물학교실
  • 직위교수
  • 세부전공생화학/면역학
  • 연구실위치문숙의학관 306호
  • 구내전화번호02-2286-1192
  • 팩스02-923-0480
  • 이메일biojs@korea.ac.kr
학력사항
1979. 3 - 1985. 2 의학사, 고려대학교 의과대학 의학
1985. 3 - 1987. 2 의학석사, 고려대학교 의과대학 의학과 (생화학전공)
1987. 9 - 1992. 12 박사, Tufts University, Boston, MA, USA (면역학 전공)
교육 및 경력사항
1986. 9 - 1987. 8 UNU fellowship (Tufts University/New England Medical Center)
1993. 3 - 현재 고려대학교 의과대학 생화학교실 교수
2002. 3 - 2003. 2 Visiting assoicate professor, Department of growth and development, School of Dentistry, UCSF, San Francisco, CA, USA
2005. 9 - 2009. 8 고려대학교 의과대학 생화학교실 주임교수
2005. 9 - 2009. 8 고려대학교 분자영양의학 연구소 소장
2005. 1 ~ 현재 대한생화학 분자생물학회 대의원
2007. 1 ~ 2008. 12 대한생화학 분자생물학회 운영위원장
2012. 1 ~ 2012. 12 생화학 분자생물학회 부회장
2013. 1 ~ 2013. 12 생화학 분자생물학회 선거위원회 위원장
2013. 8 ~ 현재 고려대학교 대학원 해부병리계 주임교수
2013. 8 ~ 현재 고려대학교 의과대학 기초의학위원장
대표논문
Moon J, Yu S-J, Kim H-S, and Sohn J Induction of G1 cell cycle arrest and p27KIP1 increase by panaxydol isolated from Panax ginseng. Biochem Pharm 2000. 59:1109-16

Ji JD, Choi SJ, Kim YR, Cheon HJ, Lee YH, Kim TH, Jun JB, Chae IJ, Song GG, Yu DH, Kim SY, and Sohn J Effects of PPARgamma on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes. J Autoimmun 2001. 17(3):215-21

Cheon H, Yu SJ, Yoo DH, Chae IJ, Song GG, and Sohn J. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol 2002. 127(3):547-52

Yu S-J, Kim HS, Cho S-W, and Sohn J IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1 Exp Mol Med 2004 36(4): 372-9

Cheon H, Sun YK, Yu SJ, Lee YH, Ji JD, Song GG, Lee JH, Kim MK and Sohn J Platelet-derived growth factor-AA increases IL-1β and IL-8 expression and activates NF-κB in rheumatoid fibroblast-like synoviocytes Scand J Immunol 2004 60(5):455-62

Lee JY, Yu SJ, Park YG, Kim J, Sohn J GSK-3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation Mol Cell Biol 2007 27(8):3187-3198

Cheon H, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J. Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages. Exp Mol Med 2007 39(4):524-34.

Kim JE, Koo KH, Kim YH, Sohn J, Park YG. Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model. Exp Mol Med 2008 Dec 31;40(6):709-20.

Lee JY, Kim HS, Kim JY, Sohn J. Nuclear translocation of p21(WAF1/CIP1) protein prior to its cytosolic degradation by UV enhances DNA repair and survival. Biochem Biophys Res Commun 2009 390(4):1361-6.

Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD. Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta. J Immunol 2010 185(10):5926-34.

Lee BN, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Kim Y, Lee JY, Sohn J, Ji JD. Upregulation of interleukin-1β production by 1,25-dihydroxyvitamin D(3) in activated human macrophages. Mol Biol Rep 2011 38(3):2193-201

Kim JY, Yu S-J, Oh HJ, Lee JY, Kim Y, Sohn J. Panaxydol induces apoptosis through an increased intracellularcalcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species Apoptosis 2011. 16(4):347-58

Kim HD, Jang C-Y, Choe JM, Sohn J, Kim J. Phenylbutyric acid induces the cellular senescence through an Akt/p21WAF1 signaling pathway. Biochem Biophys Res Commun 2012. 422:213?8

Kim HD, Yu SJ, Kim HS, Kim YJ, Choe JM, Park YG, Kim J, SohnJ. IL-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK. J Biol Chem 2013. 288:28743-54 (IF 4.651)

Kim TH, Lee B, Kwon E, Choi SJ, Lee YH, Song GG, Sohn J, Ji JD. Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes/macrophages. Immunol Lett. 2013 154(1-2):80-5
연구(실) 소개
본 연구실은 세포의 암화 기전을 이해하기 위하여, 세포의 증식과 노화, 사멸을 조절하는 기전을 연구하고 있음.

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