Ok Sarah Shin Professor
신옥 / Ok Sarah Shin
- Majorinfection immunology
- Lee JK, Oh SJ, Gim JA, Shin OS. miR-10a, miR-30c, and miR-451a encapsulated in small extracellular vesicles are pro-senescence factors in human dermal fibroblasts. Journal of Investigative dermatology. Accepted 2022
Lee JH, Oh SJ, Yun J, Shin OS. Nonstructural Protein NS1 of Influenza Virus Disrupts Mitochondrial Dynamics and Enhances Mitophagy via ULK1 and BNIP3. Viruses. 2021 Sep 15;13(9):1845
Oh SJ, Shin OS. SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response. Cells. 2021 Mar 2;10(3):530.
Lee JK, Kim JA, Oh SJ, Lee EW, Shin OS. Zika Virus Induces Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL)-Mediated Apoptosis in Human Neural Progenitor Cells. Cells. 2020 Nov 16;9(11):2487.
Seong RK, Lee JK, Cho GJ, Kumar M, Shin OS. mRNA and miRNA profiling of Zika virus-infected human umbilical cord mesenchymal stem cells identifies miR-142-5p as an antiviral factor. Emerging Microbes & Infection. 2020 Dec;9(1):2061-2075.
Oh SJ, Gim JA, Lee JK, Park H, Shin OS. Coxsackievirus B3 Infection of Human Neural Progenitor Cells Results in Distinct Expression Patterns of Innate Immune Genes. Viruses. 2020 Mar 17;12(3):325.
Seong RK, Lee JK, Shin OS. Zika Virus-Induction of the Suppressor of Cytokine Signaling 1/3 Contributes to the Modulation of Viral Replication. Pathogens. 2020 Feb 27;9(3):163.
Gim E, Shim DW, Hwang I, Shin OS, Yu JW. Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner. Immune Network 2019 Dec 23;19(6):e40.
Oh SJ, Lee JK, Shin OS. Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity. Immune Network 2019 Nov 14;19(6):e37
Lee JK, Oh SJ, Park H, Shin OS. Recent Updates on Research Models and Tools to Study Virus-Host Interactions at the Placenta. Viruses. 2019 Dec 18;12(1).
Lee HS, Noh JY, Shin OS, Song JY, Cheong HJ, Kim WJ. MatrixMetalloproteinase-13 in Atherosclerotic Plaque Is Increased by Influenza A Virus Infection. Journal of Infectious Diseases. 2020 Jan 2;221(2):256-266.
Oh SJ, Lim S, Song MJ, Ahn JH, Lee CH, Shin OS. Whole Transcriptome Analyses Reveal Differential mRNA and microRNA Expression Profiles in Primary Human Dermal Fibroblasts Infected with Clinical or Vaccine Strains of Varicella Zoster Virus. Pathogens. 2019 Oct 10;8(4).
Khan A#, Shin OS#, Na J, Kim JK, Seong RK, Park MS, Noh JY, Song JY, Cheong HJ, Park YH, Kim WJ. A Systems Vaccinology Approach Reveals the Mechanisms of Immunogenic Responses to Hantavax Vaccination in Humans. Scientific Reports. 2019 Mar 18;9(1):4760. (#co-first authors)
Lee JK, Shin OS. Advances in Zika Virus？Host Cell Interaction: Current Knowledge and Future Perspectives. International Journal of Molecular Sciences. 2019 Mar 4;20(5).
Kim JA, Seong RK, Son SW, Shin OS. Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes. Journal of Investigative Dermatology. 2019 Feb;139(2):391-399.
Seo SW, Park SK, Oh SJ, Shin OS. TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts. PLoS One. 2018 Aug 17;13(8):e0202323.
Kim JA, Seong RK, Kumar M, Shin OS. Favipiravir and Ribavirin Inhibit Replication of Asian and African Strains of Zika Virus in Different Cell Models. Viruses. 2018 Feb 9;10(2).
Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS*. Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication. Immunobiology. 2017 Nov;222(11):979-988.
- Lab Intro
- 1. Host-pathogen interaction/Innate immune signaling
TLRs and NLRs are key receptors of the host innate immune system and crucial to the pathogenesis of a variety of inflammatory human diseases. Understanding the mechanisms by which these receptors recognize microbes and other danger signals and of how they activate inflammatory signaling pathways is therefore very important to study. To reveal the complex relationship between host and pathogen, and to contribute to the development of better therapeutic agents against pathogens, we will utilize viral infection model system (such as Varicella Zoster Virus, Zika virus, Influenza virus) for dissecting host responses to pathogens and for elucidating mechanisms of microbial pathogenesis.
2. Effect of Immunosenescence on Infectious Diseases
Immunosenescence, aging associated with a decline in immune function, leads to progressive deterioration in both innate and adaptive immune functions. These changes contribute to the subsequent increased risk for infectious diseases. Each year, influenza virus infection causes severe morbidity and mortality, specifically targeting the elderly, the most susceptible group. Vaccination is the most effective and inexpensive public health strategy for prevention of influenza infection, however, the efficacy of vaccines decreases in the elderly due to immunosenescence. Therefore, we aim to elucidate age-related changes in innate and adaptive immune system using in vitro and in vivo model and to correlate such changes with responsiveness to vaccines and susceptibility to influenza infection. Thus, these studies will be helpful for the development of more effective vaccine for the elderly.