고려대학교 의과대학 및 의과학연구지원센터 구성원이 아닌 경우에는 본인인증을 통하여 글을 작성할 수 있습니다.
- 본인인증 후 글을 작성할 수 있습니다.
내 명의의 휴대전화로 비밀번호를 재설정 할 수 있습니다.
The use of renin-angiotensin-aldosterone system inhibitors and severe COVID-19 outcomes in patients with hypertension
- A nationwide cohort study shows that confirmed COVID-19 patients who have been treated with RAAS inhibitors do not need to stop such agents owing to adverse outcomes
- Professor Jae Hyun Bae and colleagues has published a review article about COVID-19 and diabetes mellitus in Nature Reviews Endocrinology
Researchers at the Korea University Anam Hospital and Korea University College of Medicine have shown that the use of renin-angiotensin-aldosterone system (RAAS) inhibitors do not increase the risk of severe outcomes in patients with hypertension and coronavirus disease 2019 (COVID-19). The results have been published in Diabetes & Metabolism Journal.
Angiotensin-converting enzyme 2 (ACE2) serves as an entry receptor for the SARS-CoV-2, the causative agent of the COVID-19, and can be associated with the risk of severe COVID-19. However, ACE2 may mitigate the progression of COVID-19 owing to its anti-inflammatory and cardioprotective effects. Therefore, there have been debates regarding benefits or harms related to the use of RAAS inhibitors during the COVID-19 pandemic.
As the COVID-19 pandemic continues to spread, the Health Insurance Review and Assessment Service of South Korea shared the nationwide COVID-19 patient data in conjucntion with the Korea Centers for Disease Control and Prevention. The researchers investigated the association of the use of RAAS inhibitors with severe COVID-19 outcomes in hypertensive patients. Of 1,374 patients with hypertension and COVID-19, 58.2% and 43.2% had diabetes mellitus and cardiovascular diseases, respectively. In this study, they found that the use of RAAS inhibitor was not associated with an increased risk of severe outcomes, including intensive care unit admission, invasive mechanical ventilation, continuous renal replacement therapy, extracorporeal membrane oxygenation, and death from COVID-19. However, RAAS inhibitor use was significantly associated with a 56% reduction in the risk of intensive care unit admission compared to the control group, particularly in patients who did not require invasive mechanical ventilation.
Professor Sin Gon Kim, a chief of Division of Endocrinology at the Korea University Anam Hospital and a leader of this study group, said: “RAAS inhibitors are widely used in the treatment of hypertension. This study shows that confirmed COVID-19 patients who have been treated with RAAS inhibitors do not need to stop such agents because of the concerns about adverse outcomes. These results also support recommendations from international societies to continue RAAS inhibitors for patients with hypertension, ischemic heart disease, or heart failure, and so on. The noteworthy finding in this study is that RAAS inhibitors may have different effects depending on the affected organs and tissues, which requires further investigation.”
Meanwhile, Professor Jae Hyun Bae, a co-first author of the paper, and colleagues has recently published a review article about COVID-19 and diabetes mellitus in Nature Reviews Endocrinology.
Publication: “Use of Renin-Angiotensin-Aldosterone System Inhibitors and Severe COVID-19 Outcomes in Patients with Hypertension: A Nationwide Cohort Study” Jae Hyun Bae, Sun Kyu Choi, Nam Hoon Kim, Juneyoung Lee, and Sin Gon Kim. Diabetes & Metabolism Journal. Published online: February 22, 2021. doi: 10.4093/dmj.2020.0279.
New Drive for Nurturing Convergent Creative Talents
Korea University College of Medicine Created Department of Medical Informatics
Korea University College of Medicine (Dean Young-Wook Yoon) newly created the Department of Medical Informatics, leading the promotion of doctors of future generations and multidisciplinary research.
Medical Informatics is found at the intersection of healthcare and technology. It is where skills in both medical and computer sciences come together to research data generated in various fields of medicine. Due to the rapid development of big data and AI which are represented by the 4th industrial revolution, the importance and number of medical science research based on medical informatics have increased.
In line with this new trend, Korea University College of Medicine created the department to nurture innovative talents who can create new forms of medical services such as telemedicine and virtual hospitals with the management and refinement of health data and create an efficient medical system with standardization of medical data.
The department plans to offer various courses such as up-to-date medical informatics, R programming, Python, up-to-date medical statistics, and medical imaging informatics. In particular, since medical informatics is based on a scientific approach to various medical data generated in the clinical field, not only faculty members but clinical adjunct professors will be assigned to facilitate clinical and organic cooperative research.
The department will play a pivotal role in creating an R&D campus in Jeongneung based on data; KU Medicine will relocate in the second half of this year thereto. Together with KU Medicine’s Medical Intelligence & Data Hub, it is expected to lead data and information-based-future and further accelerate the transition to become a hub of global bio-medical convergent research.
“The creation of the Department of Medical Informatics will not only contribute substantially to the development of medicine by leading research that reflects the medical field but also play a pivotal role in cultivating multidisciplinary convergent talents of the future,” said Dean of College of Medicine Young-Wook Yoon. “In the future, we will make efforts to handle comprehensive medical information and become a world-leading educational institution with an academic approach.”
Development of Electroceuticals that Can Dramatically Decrease Preterm Delivery
KU College of Medicine Receives Accreditation from Korean Institute of Medical Education and Evaluation for the Highest Grade