신옥 / Ok Sarah Shin
- 1998-2002 Clark University (클락대학교), Worcester, MA, U.S.A (B.A. in Biology)
- 2002-2003 Clark University (클락대학교), Worcester, MA, U.S.A (M.A. in Biology)
- 2004-2009 Tufts University (터프츠대학교), Boston, MA, U.S.A (Ph.D in Immunology)
- 교육 및 경력사항
- 2002-2004 Research Associate, University of Massachusetts (UMASS) Medical School
- 2009-2010 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA
- 2010-2011 Division of Infectious Diseases, Harvard Medical School /Massachusetts General Hospital (MGH), Boston, MA
- 2011-2013 고려대학교 생명과학부/CJ 식품안전관 연구교수
- 2013-2016 고려대학교 의과대학 대학원 조교수
- 2016- 현재 고려대학교 의과대학 대학원 부교수
- 연구(실) 소개
- 1. Host-pathogen interaction/Innate immune signaling
TLRs and NLRs are key receptors of the host innate immune system and crucial to the pathogenesis of a variety of inflammatory human diseases. Understanding the mechanisms by which these receptors recognize microbes and other danger signals and of how they activate inflammatory signaling pathways is therefore very important to study. To reveal the complex relationship between host and pathogen, and to contribute to the development of better therapeutic agents against pathogens, we will utilize viral infection model system (such as Varicella Zoster Virus, Zika virus, Influenza virus) for dissecting host responses to pathogens and for elucidating mechanisms of microbial pathogenesis.
2. Effect of Immunosenescence on Infectious Diseases
Immunosenescence, aging associated with a decline in immune function, leads to progressive deterioration in both innate and adaptive immune functions. These changes contribute to the subsequent increased risk for infectious diseases. Each year, influenza virus infection causes severe morbidity and mortality, specifically targeting the elderly, the most susceptible group. Vaccination is the most effective and inexpensive public health strategy for prevention of influenza infection, however, the efficacy of vaccines decreases in the elderly due to immunosenescence. Therefore, we aim to elucidate age-related changes in innate and adaptive immune system using in vitro and in vivo model and to correlate such changes with responsiveness to vaccines and susceptibility to influenza infection. Thus, these studies will be helpful for the development of more effective vaccine for the elderly.
3. Development of novel adjuvants: Modulation of Innate Immunity
Adjuvants have been traditionally used to enhance the magnitude of an adaptive immune response to a vaccine. Developing highly active, efficient and safe adjuvants for use in human vaccines remains both a challenge and a necessity. Several agonists for TLRs or NLRs have been considered for use as adjuvants, however, the efficacy of each adjuvants may differ depending on the age or immune activation state of individuals. Therefore, identifying and determining proper personalized adjuvants is important for maximizing vaccine efficacy. We aim to develop quick and easy screening tools that allow us to track single vs. combined effect of several adjuvants and additional nutrients in the activation of adaptive immunity and identify the best candidates for different types of vaccines.