기초교실 - 교수진 소개

김동훈 교수

김동훈 교수

김동훈 / Dong-Hoon Kim

  • 소속약리학교실
  • 직위주임교수
  • 세부전공에너지대사질환 약리학
  • 연구실위치의학관 3305호
  • 구내전화번호02-2286-1237
  • 팩스02-927-0824
  • 이메일LDHKIM@korea.ac.kr
학력사항
1996 고려대학교 의학과/학사
1999 고려대학교 대학원 의학과/석사
2004 고려대학교 대학원 의학과/박사
2005 고려대학교 대학원 약리학, BK21연구교수
2010 University of Cincinnati, Internal Medicine, Metabolic Disease Institute, Postdoctoral fellow
교육 및 경력사항
2010 ~ 현재 고려대학교 의과대학 교수
학술활동
2011 ~ 현재 대한약리학회
2011 ~ 현재 고려인삼학회
대표논문
● Depot-specific differences in angiogenic capacity of adipose tissue in differential susceptibility to diet-induced obesity. Mol metab. 2016
● Involvement of S6K1 in mitochondria function and structure in HeLa cells. Cell Signal. 2016
● FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016
● Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma. Oncotarget. 2016
● The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice. J Ginseng Res. 2016
● The effect of metformin on neuronal activity in the appetite-regulating brain regions of mice fed a high-fat diet during an anorectic period. Physiol Behav. 2016
● Adipocyte glucocorticoid receptors mediate fat-to-brain signaling. Psychoneuroendocrinology. 2015
● Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity. Diabetes 2015
● The role of the transcription factor ETV5 in insulin exocytosis. Diabetologia. 2014
● New players in high fat diet-induced obesity: LETM1 and CTMP. Metabolism. 2014
● Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase. Am J Physiol Regul Integr Comp Physiol. 2013
● Increased adipose tissue hypoxia and capacity for angiogenesis and inflammation in young diet-sensitive C57 mice compared with diet-resistant FVB mice. Int J Obes. 2013
● Metformin decreases meal size and number and increases c-Fos expression in the nucleus tractus solitarius of obese mice. Physiol Behav. 2013
● Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes. 2012
● Expression of New Loci Associated with Obesity in Diet-Induced Obese Rats: from Genetics to Physiology. Obesity. 2012
● Hypothalamic Akt/PKB signaling in food intake regulation. Front Biosci. 2012
● The role of adipose tissue vasculature in energy balance. J Korean Soc Pediatr Endocrinol. 2011
● Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight. Diabetes. 2010
● The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis. Endocrinology. 2009
● The effects of GLP-1 infusion in the hepatic portal region on food intake. Regul Pept. 2009
● The role of GM-CSF in adipose tissue inflammation. Am J Physiol Endocrinol Metab. 2008
● Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing. Diabetes. 2008
연구(실) 소개
본 연구실은 통합과정 대학원생을 모집하고 있습니다. 연구주제에 관심 있는 학생은 연락 바랍니다.

Our research interests focus on regulation of energy balance and glucose homeostasis in the CNS and periphery. Our studies have focused on the role of adipose tissue vasculature and inflammation in the regulation of energy balance and glucose homeostasis connected with the hypothalamic control system. We have shown the interaction between CNS and periphery in the control of food intake and glucose regulation related to adipose tissue vasculature, and studied its underlying molecular and behavioral mechanisms. To extend our understanding of the previously unknown crosstalk between the status of adipose tissue vasculature and CNS, we have developed an integrated behavioral analysis system for evaluation of energy balance-related behavior and also established a variety of ways, such as a customized software to measure adipocyte morphology with hypoxia or vascular density at the same time in the same field of image acquired from an immunohistochemical staining.
Our goal is to determine the role of adipose tissue vasculature in the regulation of energy and glucose homeostasis by providing molecular and behavioral mechanisms of its interaction with other important signals within the white adipose tissue as well as the integrated whole body system.
기타사항(특허, 저서, fellowship, Awards 등)
· Ethan Sims Young Investigator Award Finalists (The Obesity Society 28th Annual Scientific Meeting)
· Travel Award (National Institute of Health)
· 보건복지부장관상

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