기초교실 - 교수진 소개

최상현 교수

최상현 교수

최상현 / Sang-Hyun Choi

  • 소속약리학교실
  • 직위교수
  • 세부전공신경면역약리학
  • 연구실위치
  • 구내전화번호6289
  • 팩스02-927-0824
  • 이메일shchoi@korea.ac.kr
학력사항
1988 고려대학교 의학과 / 의학사
1990 고려대학교 의학과 / 의학석사
1993 고려대학교 의학과 / 의학박사
교육 및 경력사항
1996 ~ 현재 고려대학교 의과대학 교수
학술활동
1988 ~ 현재 대한약리학회
대표논문
● High fat diet altered the mechanism of energy homeostasis induced by nicotine and withdrawal in C57BL/6 mice. Mol Cells 30:219-26, 2010, Hur YN, Hong GH, Choi SH, Shin KH, Chun BG
● Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain. Eur J Pharmacol 589:58-65, 2008, Park SH, Seo YH, Moon BH, Choi SH, Kang S, Lee KJ, Choi SH, Lee MS, Chun BG, Shin KH.
● Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes. Eur J Pharmacol 571(2-3):106-15, 2007, Choi JH, Kim DH, Yun IJ, Chang JH, Chun BG, Choi SH.
● Identification and characterization of novel activity-dependent transcription factors in rat cortical neurons. J Neurochem 100:269-78, 2007, Sun W, Choi SH, Park SK, Kim SJ, Noh MR, Kim EH, Kim HJ, Kim H.
● Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects. Clin Pharmacol Ther 79:590-9, 2006, Park JY, Kim KA, Park PW, Lee OJ, Kang DK, Shon JH, Liu KH, Shin JG.
● Identification of process-localized mRNAs from cultured rodent hippocampal neurons. J Neurosci 26:13390-9, 2006, Poon MM, Choi SH, Jamieson CA, Geschwind DH, Martin KC.
● Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats. Neuropharmacology 50:824-33, 2006, Kim SJ, Park SH, Choi SH, Moon BH, Lee KJ, Kang SW, Lee MS, Choi SH, Chun BG, Shin KH.
● Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration. Neurobiol Dis 22:302-11, 2006, Coppola G, Choi SH, Santos MM, Miranda CJ, Tentler D, Wexler EM, Pandolfo M, Geschwind DH.
● Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. Exp Mol Med 38:44-54, 2006, Lee KJ, Kim SJ, Kim SW, Choi SH, Shin YC, Park SH, Moon BH, Cho E, Lee MS, Choi SH, Chun BG, Shin KH.
● Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain. Biochem Biophys Res Commun 327:848-56, 2005, Sun W, Park KW, Choe J, Rhyu IJ, Kim IH, Park SK, Choi B, Choi SH, Park SH, Kim H.
● Arginine deiminase enhances dexamethasone-induced cytotoxicity in human T-lymphoblastic leukemia CCRF-CEM cells. Int J Cancer 112:502-8, 2004, Noh EJ, Kang SW, Shin YJ, Choi SH, Kim CG, Park IS, Wheatley DN, Min BH.
● Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radic Biol Med 33:1321-33, 2002, Choi DH, Kim DH, Park YG, Chun BG, Choi SH.
● Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes. Free Radic Biol Med 32:394-405, 2002, Choi SH, Choi DH, Lee JJ, Park MS, Chun BG.
● Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. J Neurosci Res 67:411-21, 2002, Choi SH, Choi DH, Song KS, Shin KH, Chun BG.
● Cytoprotective effect of arginine deiminase on taxol-induced apoptosis in DU145 human prostate cancer cells. Mol Cells 10:331-7, 2000, Kang SW, Kang H, Park IS, Choi SH, Shin KH, Chun YS, Chun BG, Min BH.
● Antisense oligonucleotide of clusterin mRNA induces apoptotic cell death and prevents adhesion of rat ASC-17D Sertoli cells. Mol Cells 10:193-8, 2000, Kang SW, Lim SW, Choi SH, Shin KH, Chun BG, Park IS, Min BH.
● Polyamine-depletion induces p27Kip1 and enhances dexamethasone-induced G1 arrest and apoptosis in human T lymphoblastic leukemia cells. Leuk Res 24:119-27, 2000, Choi SH, Kim SW, Choi DH, Min BH, Chun BG.
● Guanosine 5',3'-cyclic monophosphate enhances lipopolysaccharide-induced nitric oxide synthase expression in mixed glial cell cultures of rat. Neurosci Lett 276:29-32, 1999, Choi SH, Shin KH, Kang SW, Chun YS, Chun BG.
연구(실) 소개
The Choi’s Lab is interest in figuring out the cellular and molecular biology of glial cells with respect to neuro-glial interactions and neurodegeneration. One of our current concerns is the balance between NF-kappaB and Nrf2/ARE pathways governing the homeostasis of microglial activity.

Another methodological interest is connected with the application of DNA microarray technology for genome-wide gene expression analysis and gene discovery.

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