기초교실 - 생리학교실

김경미 교수

김경미 교수

김경미 / Kyoungmi Kim

  • 소속생리학교실
  • 직위부교수
  • 세부전공발생학/유전자편집
  • 연구실위치문숙의학관 724호
  • 구내전화번호1232
  • 팩스02-925-5492
  • 이메일kim0912@korea.ac.kr
학력사항
2013 Ph.D. Ewha Womans University
2007 M.S. Gyeongsang National University
2005 B.S. Gyeongsang National University
교육 및 경력사항
2021 - present Associate Professor, Department of Physiology,
Korea University College of Medicine
2018 - 2020 Assistant Professor, Department of Physiology,
Korea University College of Medicine
2014 - 2018 Research Fellow, Institute for Basic Science (IBS)
2013 - 2014 Postdoctoral Fellow, Ewha Womans University
2004 International Program Associate, RIKEN, Japan
대표논문
1. Soo-Ji Park, Tae Yeong Jeong, Seung Kyun Shin, Da Eun Yoon, Soo-Yeon Lim, Sol Pin Kim, Jungmin Choi, Hyunji Lee, Jeong-Im Hong, Jinhee Ahn, Je Kyung Seong*, and Kyoungmi Kim*. Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor. Genome Biology. 2021 Jun 3;22(1):170.

2. Hyunji Lee, Da Eun Yoon, Kyoungmi Kim*. Genome editing methods in animal models. Animal Cells Systems. 2020; 17;24(1):8-16.

3. Sojin Kim, Youngbeom Seo, Tamrin Chowdhury, Hyeon Jong Yu, Chae Eun Lee, Kyung-Min Kim, Ho Kang, Hak Jae Kim, Soo-Ji Park, Kyoungmi Kim, Chul-Kee Park. Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells. Scientific Reports. 2020: 26;10(1):18238.

4. Seuk-Min Ryu, Junseok W Hur & Kyoungmi Kim*. Evolution of CRISPR towards accurate and efficient mammal genome engineering. BMB Reports. 2019; 52(8): 475-481.

5. Sunghyeok Ye, Woo-Keun Kwon, Taegeun Bae, Sunghyun Kim, Jang-Bo Lee, Tai-Hyoung Cho, Jung-Yul Park, Kyoungmi Kim, Junho K Hur, Junseok W Hur. CCN5 Reduces Ligamentum Flavum Hypertrophy by Modulating the TGF-β Pathway. Journal of Orthopaedic Research. 2019 Dec;37(12):2634-2644.

6. Seuk-Min Ryu*, Taeyoung Koo*, Kyoungmi Kim*, Kayeong Lim*, Gayoung Baek, Sang-Tae Kim, Heon Seok Kim, Da-eun Kim, Hyunji Lee, Eugene Chung & Jin-Soo Kim. Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy. Nature Biotechnology. 2018 Jul;36(6):536-539. (*Equal contribution).

7. Sang-Tae Kim, Jeongbin Park, Daesik Kim, Kyoungmi Kim, Sangsu Bae, Matthias Schlesner and Jin-Soo Kim. Response to “Unexpected mutations after CRISPR?Cas9 editing in vivo” 1 by Schaefer et al. Nature methods. 2018 March 30, 15 (4): 239-240.

8. Daesik Kim*, Kayeong Lim*, Sang-Tae Kim, Sun-heui Yoon, Kyoungmi Kim, Seuk-Min Ryu and Jin Soo Kim. Genome-wide target specificities of CRISPR RNA-guided programmable deaminases. Nature Biotechnology. 2017 May;35(5):475-480.

9. Kyoungmi Kim*, Seuk-Min Ryu*, Sang-Tae Kim, Gayoung Baek, Daesik Kim, Kayoung Lim, Eugene Chung, Sunghyun Kim & Jin-Soo Kim. Highly efficient RNA-guided base editing in mouse embryos. Nature Biotechnology. 2017 May;35(5):435-437. (*Equal contribution).

10. Kyoungmi Kim*, Sung Wook Park*, Jin Hyoung Kim, Seung Hwan Lee, Daesik Kim, Taeyoung Koo, Jeong Hun Kim, Jin-Soo Kim. Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration. Genome research. 2017 Mar;27(3):419-426. (*Equal contribution).

11. Eunji Kim*, Taeyoung Koo*, Sung Wook Park*, Daesik Kim, Kyoungmi Kim, Hee-Yeon Cho, Dong Woo Song, Kyu Jun Lee, Min Hee Jung, Seokjoong Kim, Jin Hyoung Kim, Jeong Hun Kim and Jin-Soo Kim. In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni. Nature communications. 2017 Feb 21;8:14500.

12. Junho K Hur*, Kyoungmi Kim*, Kyung Wook Been, Gayoung Baek, Sunghyeok Ye, Junseok W Hur, Seuk-Min Ryu, Youn Su Lee & Jin-Soo Kim. Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins. Nature Biotechnology. 2016 Aug;34(8):807-8. (*Equal contribution).
연구(실) 소개
<연구실 소개>

본 연구실은 CRISPR 시스템 기반의 새로운 유전체 편집 기술 개발 및 이를 활용한 유전성/후천성 질환 치료를 위한 유전자/세포 치료법 개발 연구들을 진행하고 있습니다.

1. Genome surgery using Cas9 ribonucleoproteins (RNPs) for the treatment of age-related macular degeneration (AMD). Korea, America and PCT Patent, 2016. (10-2017-0095685 / PCTK2017008122 / US 15_661,300 / US 62_367,674).
2. Highly efficient RNA-guided base editing in mouse embryos. Korea Patent, 2017. (10-2016-0178429).
3. RNA-guided genome editing in animal and plant by Cpf1. Korea and PCT Patent, 2016. (10-2016-0036381 / 10-2016-0167045 / PCTKR2016014379).

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